Effects of pelamine and impulse currents on microcirculation in the rabbit ear

Abstract

Aim. To compare the effectiveness of the impact of pulsed currents from the ELAV-8 device and the combined effect of pulsed currents and biologically active agent «Pelamine» on microcirculation in the rabbit ear.Materials and methods. Experiments were carried out on six rabbits of the same weight and one litter. The ears of rabbits were used as the object of the study because they are pretty thin and covered with a small amount of wool, and the vessels of the ear are well visualized. The effect of pulsed electric currents from the ELAV–8 device and the biologically active substance «Pelamine» on microcirculation in the rabbit ear was investigated for the first time.Results and discussion. As a result of our experiments, we found that pulse currents from the ELAV-8 device with a frequency of 50 and 100 Hz have a vasodilatory effect on the microcirculatory bed of the rabbit’s ear vessels. When exposed to a current with a frequency of 100 Hz, the effect of vasodilation was 5% higher than at a frequency of 50 Hz. The biologically active agent «Pelamine» applied to the rabbit’s paravertebral region using pulsed currents from the ELAV-8 device causes a vasodilator effect and the formation of additional collaterals in the rabbit’s ear. When exposed to a current with a frequency of 100 Hz, the effect of vasodilation was 6% higher than at a frequency of 50 Hz. The effect of vasodilation, when exposed to pulsed currents from the ELAV-8 device, reaches its maximum at the 5th-10th minute. The introduction of the biologically active agent «Pelamine» with the help of currents from the ELAV-8 device has a more prolonged effect on the expansion of the vascular bed. The changes are consistent and reach the maximum effect at the 15th minute.Conclusions. We have shown that the combined effect of pulsed electric current from the ELAV-8 device and the biologically active agent «Pelamine» has a more prolonged effect on the expansion of the vascular bed than only pulsed currents.