CCERW: A new prediction rule to identify treatment failure patients with community-acquired pneumonia for middle aged and elderly

Abstract

To develop and validate a clinical prediction rule to identify treatment failure patients with community-acquired pneumonia(CAP) for middle aged and elderly in China, data from the patients aged ≥ 45 yrs with CAP in derivation cohort, internal validation cohort and external validation cohort were analysed by the methods of univariate analysis, multivariate analysis and receiver operating curve. The results showed a prediction rule CCERW based on five independent factors (i.e., confusion; creatinine<60µmol/L; electrolyte disturbances; respiratory failure; WBC>7.5×109/L) which correlated with treatment failure had better predictive capability than PSI, CURB65 and CRB65, and can be used in middle aged and elderly patients with CAP of Han people in China.