11. The Immuno-Carcinogen Theory of Cancer—TheLifelong Dynamic Interface Between the Immune System and the Carcinogen-Driven Carcinogenesis

Abstract

Over the decades, many theories or models of carcinogenesis have been proposed. Based on the systems epidemiology research on gene expression from immune cells in peripheral blood, the concept of the dynamic interface between the immune system and the carcinogen driven carcinogenesis is put forward. This com-bines traditional exposure research in cancer epidemiology with upcoming knowledge of the immunological response to cancer, from clones of cancer cells to clones of immune cells.