Instrumentation with attoFarad resolution for electrochemical impedance measurements on molecular biosensors

Abstract

Sub-attoFarad capacitance resolution is experimentally reached, demonstrating the suitability of the proposed instrumentation for the development of impedimetric molecular biosensors. The modular design of the system is illustrated along with novel analog solutions (providing high sensitivity over a DC-1MHz bandwidth), digital lock-in elaboration techniques and their impact on the final instrument resolution.