A Finite element method for Shear Stress study on cancer cell proliferation

Abstract

Metastatic progression of tumors requires the coordinated dissemination of cancerous cells through interstitial tissues and their replication in distant body locations. Despite their importance in cancer treatment decisions, key factors, such as cell shape adaptation and the role it plays in dense tissue invasion by cancerous cells, are not well understood. With this work, we will continue further work on the study of the effect of shear stress on cancer cell proliferation. We present a coupled Keller-Segel and Darcy-Brinkman model implemented in finite elements to obtain numerical results.