Prüfung der Tränenfilmmessungen eines multifunktionalen Instrumentes

Heiko Pult
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Abstract

Purpose. The aim of this study was to test the measurements of the tear film stability and tear meniscus height of the Visio- nix 120+ (VX; Luneau Technology, Jerusalem, Israel). Material and Methods. In 24 volunteers (mean age = 37.42 ± 14.23 (standard deviation)), the tear film stability (V-NIBUT and V-NIBUT M) and the tear meniscus height (V-TMH) were determined with VX and the gold-standard, the “Tearscope” technique, of the right eyes (control; NIBUT and TMH). The symptoms were observed using the Ocular Disease Index-6 (OSDI-6). The methods were analysed with Cohen’s Kappa and intra-class correlation (ICC), the prediction probability with the Receiver-Operator-Characteristic-Curve (ROC). Results. The average OSDI-6 grade was 8.00 ± 5.75, the average tear film stability, measured with the VX, was 3.92 s ± 1.79 (V-NIBUT) and 7.36 s ± 1.67 (V-NIBUT M), the control was 10.57 s ± 6.84. The mean tear meniscus height, measured with the VX, was 0.31 mm ± 0.10, the control 0.31 mm ± 0.11. The Cohen’s Kappa analysis showed none to slight agree- ment between methods (V-NIBUT - NIBUT: Kappa -0.005, p = 0.708; V-NIBUT M – NIBUT: Kappa 0.035, p = 0.032; V-TMH - TMH: Kappa 0.06, p = 0.051). V-NIBUT to NIBUT gave an ICC of 0.167 (p = 0.332), V-NIBUT M to NIBUT gave 0.296 (p = 0,203) and V-TMH to TMH -0.192 (p = 0.661). While NIBUT was a significant discriminator of OSDI-6, this was not the case with V-NIBUT or V-NIBUT M (NIBUT: area under the ROC (AUC) = 0.832, p = 0.009; V-NIBUT: AUC = 0.547; p = 0.145; V-NIBUT M: AUC = 0.668, p = 0.127). Conclusion. The measurements of the VX differed signifi- cantly from the control measurements. Keywords tear film stability, NIBUT, tear meniscus height, OSDI-6, dry eye
用此来麻醉你的机器
目的。本研究的目的是测试Visio- nix 120+ (VX;鲁诺技术,耶路撒冷,以色列)。材料和方法。24名志愿者(平均年龄= 37.42±14.23(标准差)),采用VX和金标准“泪镜”技术测定右眼泪膜稳定性(V-NIBUT和V-NIBUT M)和泪膜半月板高度(V-TMH)。NIBUT和TMH)。使用眼部疾病指数-6 (OSDI-6)观察症状。采用Cohen’s Kappa和类内相关性(ICC)对方法进行分析,采用receiver - operator - characteristic curve (ROC)对预测概率进行分析。结果。平均OSDI-6等级为8.00±5.75,平均泪膜稳定性(VX)为3.92 s±1.79 (V-NIBUT)和7.36 s±1.67 (V-NIBUT M),对照组为10.57 s±6.84。VX测量撕裂半月板平均高度为0.31 mm±0.10,对照组为0.31 mm±0.11。Cohen 's Kappa分析显示两种方法之间无或轻微一致(V-NIBUT -NIBUT: Kappa -0.005, p = 0.708;V-NIBUT M -NIBUT: Kappa 0.035, p = 0.032;V-TMH -TMH: Kappa为0.06,p = 0.051)。V-NIBUT对NIBUT的ICC为0.167 (p = 0.332), V-NIBUT M对NIBUT的ICC为0.296 (p = 0,203), V-TMH对TMH的ICC为-0.192 (p = 0.661)。虽然NIBUT是OSDI-6的显著鉴别因子,但V-NIBUT或V-NIBUT M并非如此(NIBUT: ROC下面积(AUC) = 0.832, p = 0.009;V-nibut: auc = 0.547;P = 0.145;V-NIBUT M: AUC = 0.668, p = 0.127)。结论。VX的测量结果与对照组的测量结果有很大的不同。泪膜稳定性,NIBUT,泪膜半月板高度,OSDI-6,干眼症
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