Rui Huang, De-Juan Yuan, Shao Li, Xue-Song Liang, Yue Gao, Xiaoyan Lan, Hua-min Qin, Yu-Fang Ma, Guang-Yin Xu, M. Schachner, V. Sytnyk, J. Boltze, Quan-Hong Ma, Shen Li
{"title":"NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis","authors":"Rui Huang, De-Juan Yuan, Shao Li, Xue-Song Liang, Yue Gao, Xiaoyan Lan, Hua-min Qin, Yu-Fang Ma, Guang-Yin Xu, M. Schachner, V. Sytnyk, J. Boltze, Quan-Hong Ma, Shen Li","doi":"10.1083/jcb.201902164","DOIUrl":null,"url":null,"abstract":"The role of NCAM in corticogenesis is incompletely understood. The authors demonstrate that NCAM controls NPC proliferation and fate decision through profilin2-dependent regulation of actin polymerization. This finding sheds new light on NCAM’s functions in neurodevelopmental and mental disorders.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.201902164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
The role of NCAM in corticogenesis is incompletely understood. The authors demonstrate that NCAM controls NPC proliferation and fate decision through profilin2-dependent regulation of actin polymerization. This finding sheds new light on NCAM’s functions in neurodevelopmental and mental disorders.
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