Exploring reconstruction of motor and sensory function through targeted reinnervation in rat mode

Abstract

Previous experiments have explored the mechanisms underlying targeted muscle regeneration (TMR) technology that is used for neurological functional reconstruction in amputees. For such studies, a useful animal model has been established and reconstruction of neural function can be studied using fine-tuned TMR techniques. The purpose of this study was to verify the feasibility of the model and to explore the mechanisms that make this type of reconstruction possible. In the present study, we reconstructed motor and sensory functions in rats using a fine-tuned TMR technique. The amplitude of electromyographic (EMG) signals gradually became stronger over time in the TMR group. The sensory signal was received and the EMG amplitude correlated with the stimulus intensity. Morphological results showed that the nerve survived in the target muscle and that tactile corpuscles existed in the skin of the TMR group. The experimental results verified the feasibility of the rat model and preliminarily explored the mechanism of neural function reconstruction.