Staphylococcal Infections

Abstract

MrrHICILLIN (sodium 6-[2,6 dimethoxybenzamido] penicillinate .monohydrate) has been the first compound of major importance resulting from the isolation of pure 6-amino penicillanic acid by Batchelor, Doyle, Nayler and Rolinson (1959). This new penicillin compound is of great therapeutic importance on account of several valuable properties which it, possesses. It is bactericidal (Knox, I960), virtually non-toxic (Brown and Acred, 1960), is unaffected by staphylococcal penicillinase (Knox, I960; Rolinson, Stevens, Batchelor, Wood and Chain, i960) and is effective against all isolated strains of staphylococci in vitro (Thompson, Harding and Simon, I960). Furthermore, it is effective against staphylococci in vivo (Douthwaite and Trafford, I960; Stewart, Nixon, Coles, Kesson, Lawson, Thomas,. Mishra, Mitchell, Semmens and: Wade, i960). Most of these findings have been confirmed by workers in Canada (Branch, Rodger, Lee'and'Power, I966). We have had the opportunit of observing the results of treatment with this compound of a number of patients infected with penicillinresistant staphylococci'in this hospital.