Development of an electronic microtiterplate for high throughput screening (HTS)

Abstract

The presented sensor system introduces a novel "electronic microtiterplate" based on conductivity measurement for different biological species (e.g. yeast or bacteria cells). The incubation of the biological species takes place in the wells of the microtiterplates. In this paper a 10 well-system corresponding to the size of a standard 1536 well microtiterplate is described. Substances as drugs, ligands or antibiotics interact with biological target structures. This interaction lead to a change of cell numbers by choosing the right biological target systems or using genetically engineered cells. The change of biomass is measured differentially by impedance measurements using an electrode array on the bottom of the microtiter wells.