Design and simulation of double lumen polymeric microneedles for blood transport

S. Tayyaba, M. Ashraf, N. Afzulpurkar
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引用次数: 7

Abstract

Blood extraction and insertion is a common process in daily life at hospitals. Hypodermic needles are mostly used for blood transport. These needles are associated with many disadvantages like pain induction due to longer length and no biocompatibility because of material used. In this paper, a novel design and simulation of double lumen polymeric microneedles for blood extraction and insertion have been presented. Using finite element software ANSYS, structural and fluidic analysis have been conducted to prophesy the mechanical strength of microneedles and fluid flow rate through the lumen regions. The effect of pressure and bending force on the tip of microneedle is investigated in structural analysis. Simulation results envisage that the resultant stress values due to applied loads are in the safe range. Fluidic analysis shows that the proposed design is suitable for blood extraction because different lumens radii are useful to avoid the clogging effect. Hot emboss and laser ablation techniques have been proposed for fabrication of double lumen out-of-plane polymeric microneedles.
用于血液输送的双腔聚合物微针的设计与仿真
抽取和插入血液是医院日常生活中常见的过程。皮下注射针头主要用于血液输送。这些针头有许多缺点,如由于长度较长而引起疼痛,并且由于使用的材料而没有生物相容性。本文介绍了一种用于血液提取和插入的双腔聚合物微针的设计和仿真。利用有限元软件ANSYS对微针进行了结构和流体分析,预测了微针的机械强度和流经腔区的流体流量。在结构分析中,研究了压力和弯曲力对微针尖端的影响。模拟结果表明,由于施加载荷而产生的应力值在安全范围内。流体分析表明,由于不同的管腔半径有助于避免堵塞效应,因此该设计适用于血液提取。提出了热压花和激光烧蚀两种制备双腔面外聚合物微针的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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