Circulating Fatty Acid Binding Protein 4 Concentration Increases with an Acute Maximal Exercise Independently of Exercise Training Status

S. Numao, Ryota Uchida, T. Kurosaki, M. Nakagaichi
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引用次数: 1

Abstract

Limited data on the response of fatty acid binding protein 4 (FABP4) to acute exercise are available. The purpose of this study was to determine the response of FABP4 to incremental maximal exercise in exercise-trained and untrained men. Eleven exercise-trained young men (T group; age, 20.4 ± 1.2 years) and 9 untrained young men (UT group; age, 20.7 ± 0.5 years) performed an incremental maximal exercise after a 12-h fasting period. Before and immediately after the incremental maximal exercise, venous blood was drawn to measure circulating FABP4, free fatty acid, and glycerol concentrations. Body composition, and aerobic capacity were also assessed. Glycerol concentration significantly increased during the exercise in the T group (group × time interaction: p = 0.034; group effect, p = 0.088; and time effect, p = 0.003), and the percentage increase in glycerol concentration was greater in the T group than in the UT group ( p = 0.046; ES( r ): 0.45). Although circulating FABP4 concentration significantly increased in the two groups (group × time interaction: p = 0.766; group effect, p = 0.114; and time effect, p = 0.001), the percentage increase in FABP4 concentration was similar ( p = 0.210; ES( r ): 0.28). Additionally, the change of FABP4 concentration was not correlated with that of glycerol (r = -0.04, p =0.872). These results indicated that circulating FABP4 concentration increased during incremental maximal exercise regardless of difference in lipolysis and exercise training status in healthy young men. circulating FABP4 concentration to an incremental maximal exercise in exercise-trained and untrained men. Our data demonstrated that despite that exercise-trained men had a greater lipolysis during the incremental maximal exercise, circulating FABP4 concentration increased similarly during this exercise in both exercise-trained and untrained men. Moreover, the change in circulating FABP4 concentration during the incremental maximal exercise was not correlated with that of FFA and glycerol. These findings suggest that circulating FABP4 concentration increases during high-intensity acute exercise regardless of the exercise training status, and the increase in circulating FABP4 concentration during high-intensity acute exercise is accompanied by the increases in blood level of glycerol in the trained but not in the untrained men. that circulating FABP4 during acute incremental maximal exercise in both exercise-trained and untrained an increase in circulating FABP4 concentration was observed in all participants. Thus, high- intensity acute exercise is more likely to increase circulating FABP4 concentration in healthy young individuals. Our findings provide further evidence of the response of circulating FABP4 men. This suggests that suppression of macrophage functions leads to attenuation of the secretion of FABP4 from macrophages in exercise-trained men. However, lack of the data specified for macrophages do not allow us a deeper discussion regarding their roles in FABP4 release during acute exercise. Further studies are required to the of circulating during increment maximal
循环脂肪酸结合蛋白4浓度随急性最大运动而增加,与运动训练状态无关
关于脂肪酸结合蛋白4 (FABP4)对急性运动的反应的数据有限。本研究的目的是确定FABP4在运动训练和未训练的男性中对增量最大运动的反应。11名接受运动训练的青年男性(T组;年龄(20.4±1.2岁),未经训练的青年男性9例(UT组;年龄(20.7±0.5岁)在禁食12小时后进行增量最大运动。在增量最大运动之前和之后立即抽取静脉血,测量循环FABP4、游离脂肪酸和甘油浓度。还评估了身体成分和有氧能力。T组运动时甘油浓度显著升高(组×时间交互作用:p = 0.034;组效应,p = 0.088;时间效应,p = 0.003),且T组甘油浓度升高百分比大于UT组(p = 0.046;ES(r): 0.45)。虽然两组患者循环FABP4浓度显著升高(组×时间交互作用:p = 0.766;组效应,p = 0.114;时间效应,p = 0.001), FABP4浓度增加百分比相似(p = 0.210;ES(r): 0.28)。此外,FABP4浓度的变化与甘油浓度的变化无相关性(r = -0.04, p =0.872)。这些结果表明,在健康青年男性中,无论脂肪分解和运动训练状态的差异如何,增加最大运动时循环FABP4浓度升高。在运动训练和未训练的男性中,循环FABP4浓度与增量最大运动的关系。我们的数据表明,尽管运动训练的男性在增量最大运动期间有更大的脂肪分解,但在运动训练和未训练的男性中,循环FABP4浓度在该运动期间相似地增加。此外,增加最大运动期间循环FABP4浓度的变化与FFA和甘油的变化无关。这些结果表明,无论运动训练状态如何,高强度急性运动期间循环FABP4浓度升高,且高强度急性运动期间循环FABP4浓度升高伴随着血液中甘油水平的升高,而未训练的男性则没有。在运动训练和未训练的急性增量最大运动期间,所有参与者都观察到循环FABP4浓度增加。因此,高强度的急性运动更有可能增加健康年轻人的循环FABP4浓度。我们的发现为循环FABP4男性的反应提供了进一步的证据。这表明,在运动训练的男性中,巨噬细胞功能的抑制导致巨噬细胞FABP4分泌的衰减。然而,由于缺乏巨噬细胞的特定数据,我们无法更深入地讨论它们在急性运动期间FABP4释放中的作用。对于增量最大化时的循环,需要进一步的研究
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