Control of COVID-19 Outbreak for Preventing Collapse of Healthcare Capacity

H. Patiño, Santiago Tosetti, J. Pucheta, C. Riveros
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Abstract

Mathematical models are a powerful tool to study and predict he dynamic behaviour of processes and systems, physical and biological, as well as to assist in decision making, and to design control systems. In the case of the coronavirus pandemic, COVID-19, its dynamic behaviour is generally in line with traditional models proposed, such as the Susceptible-Infected-Recovered (SIR) or the (SEIR), that includes the Exposed, which are useful tools to estimate the spread of the virus, the number of infected, the recovered individuals, and amount of deaths, as well as finding the outbreak start, the rise time, the peak time and overshoot, and fading stage. In COVID-19, the knowledge of the maximum peak and its delay time are important to prepare the healthcare system capacity, and therefore have enough intensive care units (ICUs) with automatic ventilators. In this work, a simple but robust control strategy for sequencing social distancing and confinement is proposed. The main control objective is to control the COVID-19 outbreak to avoid the collapse of the healthcare system and saturation of ICUs capacity, generating a control action sequence of social distancing and confinement such as the number of new cases requiring ICU is below a threshold set-point. An On-Off control action is analysed, and a Proportional-Integral-Derivative (PID) controller is proposed to generate a public policy (a sequence of decisions) applied once a week or every fortnight. Simulation results showing the practical feasibility and performance of the approach are given, and somehow supporting and validating strategies carried out by many healthcare teams from many countries.
控制COVID-19疫情,防止医疗保健能力崩溃
数学模型是研究和预测物理和生物过程和系统动态行为的有力工具,也有助于决策制定和设计控制系统。在COVID-19冠状病毒大流行的情况下,其动态行为通常与提出的传统模型一致,例如易感感染恢复模型(SIR)或(SEIR),其中包括暴露模型,这些模型是估计病毒传播,感染人数,恢复人数和死亡人数的有用工具,以及发现爆发开始时间,上升时间,峰值时间和超调值,以及消退阶段。在COVID-19中,了解最大峰值及其延迟时间对于准备医疗保健系统的能力非常重要,因此可以配备足够的配备自动呼吸机的重症监护病房(icu)。在这项工作中,提出了一种简单但鲁棒的控制策略,用于对社交距离和隔离进行排序。主要控制目标是控制COVID-19疫情,避免医疗系统崩溃和ICU容量饱和,形成社会距离和限制的控制行动序列,如需要ICU的新病例数低于阈值设定点。分析了开关控制动作,并提出了比例-积分-导数(PID)控制器来生成每周一次或每两周应用一次的公共政策(一系列决策)。仿真结果显示了该方法的实际可行性和性能,并以某种方式支持和验证了来自许多国家的许多医疗保健团队执行的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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