The molecular, electrophysiological, and structural changes in the vestibular nucleus during vestibular compensation: a narrative review

Pengjun Wang, Wen Lu, Yini Li, Haibo Shi, S. Yin
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Abstract

Abstract The vestibular system involves high-level sensory and cognitive processes, such as spatial perception, balance control, visual stability, and emotional control. Vestibular dysfunction can induce vertigo, blurred vision, postural imbalance, walking instability, and spatial discomfort, which causes serious damage to health. It has long been known that after peripheral vestibular lesion, vestibular dysfunction may spontaneously recover. This is known as vestibular compensation. However, at least 20% to 30% of patients with vestibular disorders cannot yield vestibular compensation and remain with vestibular dysfunction for the rest of their lives. The exploration of the biological characteristics and regulatory factors of the loss and reestablishment of vestibular function will establish a new understanding of the mechanism of vestibular compensation and provide new tools and strategies for promoting vestibular rehabilitation. We aim to comprehensively review the mechanism of vestibular compensation and discuss future directions in this field.
前庭神经代偿过程中前庭核的分子、电生理和结构变化:述评
前庭系统涉及高级感觉和认知过程,如空间感知、平衡控制、视觉稳定性和情绪控制。前庭功能障碍可引起眩晕、视力模糊、姿势不平衡、行走不稳、空间不适等,对健康造成严重损害。人们早就知道,周围前庭病变后,前庭功能障碍可自行恢复。这被称为前庭代偿。然而,至少有20% - 30%的前庭功能障碍患者不能产生前庭代偿,并终生伴有前庭功能障碍。探索前庭功能丧失与重建的生物学特性和调控因素,将建立对前庭代偿机制的新认识,为促进前庭康复提供新的工具和策略。本文旨在对前庭神经代偿的机制进行综述,并探讨该领域的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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