A Review of the Genetic Studies and the Pathogenic Mechanism of Feline Polycystic Kidney Disease

Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is a progressive genetic disease in which multiple small and large fluid-filled sacs (cysts or cysts) are formed in one or both kidneys. Polycystic kidney disease in cats is classified as an autosomal dominant genetic disease and has been found to be caused by mutations in the PKD1 gene that is coding a unit of mechanosensitive calcium channel, polycystin 1. It shows that humans and cats share a genetic cause for polycystic kidney disease. In this paper, we try to understand the pathogenesis of polycystic kidney disease through the genetic mutations and protein functions of feline polycystic kidney syndrome reported so far, and discuss the direction of genetic research that needs to be performed in the future.