Consumption of Green Tea ( Camellia sinensis ) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation

Vivian Alves Pereira Silva, G. Boaventura, Renato de Souza Abboud, J. A. Ribas, M. Chagas
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引用次数: 5

Abstract

Indiscriminate use of anabolic steroids is associated with cardiovascular diseases, such as myocardial infarction, thrombosis, and arterial obstruction. Furthermore, high levels of androgens increase hepatic toxicity and the risk of cancer. Contrastingly, green tea prevents and controls cardiovascular and hepatic diseases, as it can improve the lipid profile and reduce inflammation and effects of oxidative stress. This study will evaluate benefits of green tea consumption, to attenuate systemic damage caused by supraphysiological doses of testosterone, by analyzing the lipid, biochemical, and hematological profiles of 28 42-day-old male Wistar rats. Silicone pellets containing testosterone in proportion were surgically implanted and replaced in these rats every four weeks, and they received casein-based control feed and water or green tea for hydration. After 20 weeks, all the male rats were anesthetized and their blood samples collected for the analysis of their biochemical and hematological profiles. Although the high hormone concentration had a negative influence on the lipid profile of these animals, the groups that consumed green tea exhibited a reduction in serum triglycerides (62%), Low Density Lipoprotein (76%), and Very Low Density Lipoprotein (45%). Tea consumption also led to a significant reduction in total cholesterol (32% in the green tea control group and 45% in the green tea-induced group), without changing the High Density Lipoprotein fraction. Only the green tea-induced group manifested a reduction in the total concentration of serum proteins. A fall in serum albumin was observed in the green tea-induced groups (2.3 g/dL) compared to control groups (2.9 g/dL). The induced group presented elevation in hematocrit, erythrocytosis, and leukocytosis in contrast to the green tea-induced group. The green tea control group maintained erythrocytosis, but without any other potentially harmful effect. A 30% increase in lymphocyte population in the induced group was observed. There was no difference in the platelet count of these rodents. Hepatic enzymes were also shown to have increased in the induced group, indicating hepatic injury in this group due to exposure to testosterone. This effect was reversed in the tea groups. From this, its possible to reach the conclusion that consumption of green tea shields the lipid profile, proteins, liver enzymes and hematological profile, thus reducing risk factors related to the supraphysiological doses of testosterone.
饮用绿茶(Camellia sinensis)可改善长期雄激素刺激大鼠的脂质、肝脏和血液学特征
不加选择地使用合成代谢类固醇与心血管疾病有关,如心肌梗死、血栓形成和动脉阻塞。此外,高水平的雄激素会增加肝毒性和患癌症的风险。相比之下,绿茶可以预防和控制心血管和肝脏疾病,因为它可以改善血脂,减少炎症和氧化应激的影响。本研究将通过分析28只42日龄雄性Wistar大鼠的脂质、生化和血液学特征,评估绿茶消费的益处,以减轻由超生理剂量的睾酮引起的全身损伤。研究人员通过手术将含有一定比例睾丸激素的硅胶颗粒植入这些大鼠体内,每四周更换一次,并给它们喂食以酪蛋白为基础的对照饲料和水或绿茶来补水。20周后,对所有雄性大鼠进行麻醉,并采集其血液样本进行生化和血液学分析。虽然高激素浓度对这些动物的脂质有负面影响,但饮用绿茶的组表现出血清甘油三酯(62%),低密度脂蛋白(76%)和极低密度脂蛋白(45%)的减少。喝茶也导致总胆固醇显著降低(绿茶对照组32%,绿茶诱导组45%),而高密度脂蛋白部分没有改变。只有绿茶诱导组表现出血清蛋白总浓度的降低。与对照组(2.9 g/dL)相比,绿茶诱导组(2.3 g/dL)血清白蛋白下降。与绿茶诱导组相比,诱导组红细胞压积、红细胞增多和白细胞增多。绿茶对照组保持了红细胞增多,但没有任何其他潜在的有害影响。诱导组淋巴细胞数量增加30%。这些啮齿类动物的血小板计数没有差异。肝酶在诱导组中也有所增加,表明这一组由于暴露于睾酮而导致肝损伤。这一效应在茶组中被逆转了。由此,我们有可能得出这样的结论:饮用绿茶可以保护脂质、蛋白质、肝酶和血液学特征,从而降低与超生理剂量睾丸激素相关的风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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