Secukinumab Associated with Acitretin in Generalized Pustular Psoriasis

Abstract

Generalized pustular psoriasis (GPP) is a severe inflammatory skin disease characterized by the presence of sterile pustules covering almost the entire body and it may be associated with systemic symptoms. There is an increasing need for specific treatment options for GPP, because this skin disorder is frequently resistant to therapies indicated for chronic plaque psoriasis. Preliminary data suggest that interleukin (IL)-17 could be a promising therapeutic target for GPP.