Paradoxical reactions during Antituberculosis therapy - A single-center prospective analysis

Abstract

Background:  Paradoxical reactions during anti-TB treatment represent a real challenge to pneumo-phthisiologists and require high index of suspicion. It has been suggested that this reaction during appropriate treatment is common and severe in HIV-negative individuals. Our objective was to determine the frequency of paradoxical reactions and their associated features. Method : A prospective study was undertaken in a population of HIV-TB+ patients to determine the frequency of paradoxical reactions and their associated features. Results: Paradoxical reactions occurred in 1.5% of all our hospital’s TB patients. Conclusion : Paradoxical reactions during anti-TB treatment is common in HIV-uninfected individuals and must be considered after careful exclusion of medication non-adherence, other infections, development of resistance, and other similar conditions.