Lymphocytes. 1. Function. Genetic restrictions in the immune response.

Abstract

The aim of this short review is to describe the role of the major histocompatibility complex (MHC) in the regulation of T lymphocyte function.This genetic complex, which includes the immune response (Ir) genes, imposes certain restrictions on the immune system. The clinical relevance of these findings is indicated by the well-known associations between particular HLA antigens and disease susceptibility. An abnormal immune response appears to play a major role in the pathogenesis of many of these diseases.