{"title":"Antigenicity of the phosphatidyl inositomannosides of mycobacteria","authors":"B. Banerjee, D. Subrahmanyam","doi":"10.1016/0161-5890(78)90131-1","DOIUrl":null,"url":null,"abstract":"<div><p>Purified di- and hexamannoside components of<em>Mycobacterium</em> 607 (<em>M</em>. 607) were analysed for their immunochemical relationships in agglutination and precipitation tests, using antisera against the MBSA complexes of total mannosides, M<sub>2</sub>-3F<sup>†</sup> and M<sub>2</sub>-4F components of dimannosides. The agglutinating antibody to total mannosides seemed to be different from that given by the precipitation test. There was no cross-reactivity between PI and the mannoside antigens, which suggested the association of antigenicity with the mannose units of the mannosides. Dimannosides with 2, 3 and 4 esters showed complete cross-reactivity. However, different antigenic specificities were found to be associated with di- and hexamannoside antigens in the immunochemical reactions. The deacylated mannoside lacked serological reactivity with antiserum to the mannosides. However, the additional fatty acids in the inositol-oligomannosyl region of the dimannosides did not seem necessary for reactivity or specificity.</p></div>","PeriodicalId":13265,"journal":{"name":"Immunochemistry","volume":"15 6","pages":"Pages 359-363"},"PeriodicalIF":0.0000,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-5890(78)90131-1","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161589078901311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Purified di- and hexamannoside components ofMycobacterium 607 (M. 607) were analysed for their immunochemical relationships in agglutination and precipitation tests, using antisera against the MBSA complexes of total mannosides, M2-3F† and M2-4F components of dimannosides. The agglutinating antibody to total mannosides seemed to be different from that given by the precipitation test. There was no cross-reactivity between PI and the mannoside antigens, which suggested the association of antigenicity with the mannose units of the mannosides. Dimannosides with 2, 3 and 4 esters showed complete cross-reactivity. However, different antigenic specificities were found to be associated with di- and hexamannoside antigens in the immunochemical reactions. The deacylated mannoside lacked serological reactivity with antiserum to the mannosides. However, the additional fatty acids in the inositol-oligomannosyl region of the dimannosides did not seem necessary for reactivity or specificity.
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