[Effect of blood serum proteins of healthy, newborn and carcinomatous rabbits on oxygen uptake by myocardium mitochondria].

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-05-01
G P Fedorova, V M Bila, V P Korotkoruchko
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Abstract

Oxygen uptake by myocardium mitochondria in healthy rabbits and those suffering from cancer was studied as affected by blood sera and beta-globulin of newborn rabbits, pregnant female rabbits, healthy and carcinomatous rabbits. Respiration of myocardium mitochondria in healthy rabbits is inhibited under the effect of sera and beta-globulin of newborn rabbits and pregnant female rabbits. But the mentioned additives produce an opposite effect on oxygen uptake by myocardium mitochondria in the rabbit suffering from cancer as compared to myocardium mitochondria in the healthy rabbit. The difference in the protein action on oxygen uptake is levelled in the animals of different groups for mitochondria destructed under the effect of temperature and supersound.

[健康兔、新生兔和患癌兔的血清蛋白对心肌线粒体摄氧量的影响]。
研究了健康兔子和癌症兔子的心肌线粒体摄氧量受新生兔子、怀孕母兔、健康兔子和癌症兔子的血清和β-球蛋白的影响。在新生兔和孕雌兔血清和 beta 球蛋白的作用下,健康兔心肌线粒体的呼吸受到抑制。但与健康兔的心肌线粒体相比,上述添加剂对癌症兔的心肌线粒体摄氧量产生了相反的影响。对于在温度和超音波作用下被破坏的线粒体,不同组别动物的蛋白质对摄氧量的作用差异是相同的。
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