[Toxic action of lindane. Biochemical and ultrastructural changes in the lysosome system in cultured hepatocytes].

F Roux, J Bescol-Liversac, C Guillam, E Fournier
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Abstract

Lindane, in contact with cultured foetal chicken liver cells over a period of 40 hours, has a biphasic action on the lysosomal system of the cells. For the concentrations between 1 micronM and 25 micronM not affecting the cellular growth, the decrease of the acid phosphatase activity and the absence of any reaction in the Golgi saccules might indicate a reduction in the synthesis of the lysosomal enzyme. For the concentrations above 25 micronM slowing down cellular growth, acid phosphatase activity is partialrogeneous content and an increase in the relative acid phosphatase activity in the soluble extralysosomal fraction, for doses over 150 micronM, might indicate the development of the phenomenon of autophagocytosis.

林丹的毒性作用。培养肝细胞溶酶体系统的生化和超微结构变化[j]。
林丹与培养的胎鸡肝细胞接触40小时以上,对细胞溶酶体系统有双相作用。在1 ~ 25 μ m的浓度范围内,酸性磷酸酶活性下降,高尔基小囊未发生任何反应,说明溶酶体酶的合成减少。对于25微米以上的浓度减缓细胞生长,酸性磷酸酶活性是部分不均匀的含量,可溶性溶酶体部分中酸性磷酸酶活性的相对增加,剂量超过150微米,可能表明自噬现象的发展。
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