Circumventing the Henderson-Hasselbalch equation

MD Donald R. Kamens, MD Robert L. Wears, MD Cleve Trimble
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引用次数: 2

Abstract

Prompt blood-gas analysis consisting of pH, PCO2, and PO2 is now almost universally accessible. PCO2 directly conveys the role of the respiratory mechanism in any acid-base disturbance. The metabolic condition, however, is hidden in a relationship between pH and PCO2 that is most faithfully expressed by the cumbersome Henderson-Hasselbalch equation (HHE). Two methods of quickly determining metabolic status from pH and PCO2, without resorting to the HHE, are discussed. The first method is well known and adjusts pH to represent only metabolic state by quantitatively cancelling the influence of hyper- or hypoventilation. The second method, not previously reported, uses measured pH to estimate the ratio HCO3/PCO2, which, when multiplied by PCO2, equals bicarbonate ion concentration.

绕过了Henderson-Hasselbalch方程
由pH、co2分压和PO2组成的快速血气分析现在几乎普遍可用。二氧化碳分压直接传达呼吸机制在任何酸碱紊乱中的作用。然而,代谢条件隐藏在pH和二氧化碳分压之间的关系中,这种关系由繁琐的Henderson-Hasselbalch方程(HHE)最忠实地表达。讨论了两种从pH和PCO2中快速测定代谢状态的方法,而无需诉诸HHE。第一种方法是众所周知的,通过定量地消除换气过度或换气不足的影响来调节pH值,仅代表代谢状态。第二种方法,以前没有报道过,使用测量的pH值来估计HCO3−/PCO2的比率,当乘以PCO2时,等于碳酸氢盐离子浓度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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