Release of putative transmitters from the corpus striatum

Abstract

The experiments reported in this article demonstrate the release of ACh, DA and 5-HT from striatal tissue. The technique used was the perfusion of the anterior horn of the lateral ventricle. The ACh and DA appearing in the perfusate must have originated from the caudate nucleus only, whereas 5-HT was probably released from terminals in the septum as well. The results support the view that the monoamines act as transmitters of impulses, and that the cells in the midbrain which contain DA and 5-HT send uninterrupted axons into different parts of the telencephalon.