The Characteristics of Entorhinal Cortex Functional Connectivity in Alzheimer's Disease Patients with Depression.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-03-03 DOI:10.2174/1567205020666230303093112

Haokai Zhu, Hong Zhu, Xiaozheng Liu, Fuquan Wei, Huichao Li, Zhongwei Guo

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引用次数: 0

Abstract

Background: Depression is one of the most common neuropsychiatric symptoms of Alzheimer's disease (AD) which decreases the life quality of both patients and caregivers. There are currently no effective drugs. It is therefore important to explore the pathogenesis of depression in AD patients.

Objective: The present study aimed to investigate the characteristics of the entorhinal cortex (EC) functional connectivity (FC) in the whole brain neural network of AD patients with depression (D-AD).

Methods: Twenty-four D-AD patients, 14 AD patients without depression (nD-AD), and 20 healthy controls underwent resting-state functional magnetic resonance imaging. We set the EC as the seed and used FC analysis. One-way analysis of variance was used to examine FC differences among the three groups.

Results: Using the left EC as the seed point, there were FC differences among the three groups in the left EC-inferior occipital gyrus. Using the right EC as the seed point, there were FC differences among the three groups in the right EC-middle frontal gyrus, -superior parietal gyrus, -superior medial frontal gyrus, and -precentral gyrus. Compared with the nD-AD group, the D-AD group had increased FC between the right EC and right postcentral gyrus.

Conclusion: Asymmetry of FC in the EC and increased FC between the EC and right postcentral gyrus may be important in the pathogenesis of depression in AD.

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抑郁症阿尔茨海默病患者大脑内皮层功能连接的特征

背景：抑郁症是阿尔茨海默病（AD）最常见的神经精神症状之一，会降低患者和护理者的生活质量。目前还没有有效的药物。因此，探索阿尔茨海默病患者抑郁症的发病机制非常重要：本研究旨在探讨抑郁症 AD 患者（D-AD）全脑神经网络中内侧皮层（EC）功能连接（FC）的特征：24名D-AD患者、14名未患抑郁症的AD患者（nD-AD）和20名健康对照者接受了静息态功能磁共振成像。我们以EC为种子，采用FC分析。我们采用单因素方差分析来研究三组患者的功能障碍差异：结果：以左侧EC为种子点，三组之间在左侧EC-枕骨下回存在FC差异。以右侧EC为种子点，三组在右侧EC-额叶中回、-顶叶上回、-额叶内上回和-中央前回存在FC差异。与 nD-AD 组相比，D-AD 组右侧 EC 和右侧中央后回之间的 FC 增加：结论：EC FC的不对称性以及EC与右侧中央后回之间FC的增加可能是AD抑郁症发病机制中的重要因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.