Sleep Characteristics in Older Adults with Different Levels of Risk for Dementia: A Cross-sectional Study.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-03-03 DOI:10.2174/1567205020666230303110244

Xiuxiu Huang, Shifang Zhang, Yuxi Fang, Xiaoyan Zhao, Ting Cao, Yongan Sun, Qiaoqin Wan

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Abstract

Background: Sleep problems are very prevalent in older adults, especially in those at risk for dementia. But the relationships between sleep parameters and subjective or objective cognitive decline are still inconclusive.

Aim: The study aimed to investigate the self-reported and objectively measured sleep characteristics in older adults with mild cognitive impairment (MCI) and subjective cognitive decline (SCD).

Methods: This study adopted a cross-sectional design. We included older adults with SCD or MCI. Sleep quality was measured separately by the Pittsburgh sleep quality index (PSQI) and ActiGraph. Participants with SCD were divided into low, moderate, and high levels of SCD groups. Independent samples T-tests, one-way ANOVA, or nonparametric tests were used to compare the sleep parameters across groups. Covariance analyses were also performed to control the covariates.

Results: Around half of the participants (45.9%) reported poor sleep quality (PSQI＜7), and 71.3% of participants slept less than 7 hours per night, as measured by ActiGraph. Participants with MCI showed shorter time in bed (TIB) (p＜0.05), a tendency of shorter total sleep time (TST) at night (p = 0.074) and for each 24-hour cycle (p = 0.069), compared to those with SCD. The high SCD group reported the highest PSQI total score and longest sleep latency than all the other three groups (p＜0.05). Both the MCI and high SCD groups had shorter TIB and TST for each 24-hour cycle than the low or moderate SCD groups. Besides, participants with multiple-domain SCD reported poorer sleep quality than those with single-domain SCD (p＜0.05).

Conclusion: Sleep dysregulation is prevalent in older adults with a risk for dementia. Our findings revealed that objectively measured sleep duration might be an early sign of MCI. Individuals with high levels of SCD demonstrated poorerself-perceived sleep quality and deserved more attention. Improving sleep quality might be a potential target to prevent cognitive decline for people with a risk for dementia.

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不同痴呆症风险水平的老年人的睡眠特征：一项横断面研究

背景：睡眠问题在老年人中非常普遍，尤其是在有痴呆风险的老年人中。目的：本研究旨在调查患有轻度认知障碍（MCI）和主观认知能力下降（SCD）的老年人自我报告和客观测量的睡眠特征：本研究采用横断面设计。我们纳入了患有 SCD 或 MCI 的老年人。睡眠质量分别通过匹兹堡睡眠质量指数（PSQI）和 ActiGraph 进行测量。患有 SCD 的参与者被分为低度、中度和高度 SCD 组。采用独立样本 T 检验、单因素方差分析或非参数检验来比较各组的睡眠参数。此外，还进行了协方差分析以控制协变量：约半数参与者（45.9%）表示睡眠质量差（PSQI＜7），71.3%的参与者每晚睡眠时间少于7小时（由ActiGraph测量）。与 SCD 患者相比，MCI 患者的卧床时间（TIB）较短（p＜0.05），夜间总睡眠时间（TST）有缩短的趋势（p = 0.074），每个 24 小时周期的总睡眠时间（TST）也有缩短的趋势（p = 0.069）。与其他三组相比，高 SCD 组的 PSQI 总分最高，睡眠潜伏期最长（p＜0.05）。与低度或中度 SCD 组相比，MCI 组和高度 SCD 组每个 24 小时周期的 TIB 和 TST 都更短。此外，多领域SCD参与者的睡眠质量比单领域SCD参与者差（P＜0.05）：结论：睡眠失调在有痴呆风险的老年人中很普遍。我们的研究结果表明，客观测量的睡眠时间可能是 MCI 的早期征兆。SCD水平较高的人自我感觉睡眠质量较差，值得更多关注。改善睡眠质量可能是预防痴呆症高危人群认知能力下降的一个潜在目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.