Effect of Polymorphisms in the FCN1, FCN2, and FCN3 Genes on the Susceptibility to Develop Rheumatoid Arthritis: A Systematic Review.

IF 2.3 Q2 RHEUMATOLOGY
Sebastián R Gil-Quiñones, Luz Gutierrez-Castañeda, Lorena Larios-Salazar, Susana Mejia-Mesa, Adriana Motta, David Tovar-Parra
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引用次数: 2

Abstract

Genetic association studies in rheumatoid arthritis conducted in various populations have yielded heterogeneous results. The present systematic review was conducted to synthesize the results of the studies in order to establish the impact of polymorphisms in the ficolin-coding genes FCN1, FCN2, and FCN3 on the susceptibility to develop rheumatoid arthritis. A systematic literature review was performed using the following keywords "gene (FCN1/FCN2/FCN3)", "Polymorphism/Genetic Variant", and "rheumatoid arthritis" in different databases until January 2022. Authors assessed articles by title/abstract and then assessed by full text for data extraction. The risk of bias was assessed using the Newcastle-Ottawa scale. Data synthesis was performed qualitatively and quantitatively. A total of 1519 articles were eligible for inclusion in this review, 3 were identified as relevant for the quantitative synthesis with 670 patients and 1019 controls. For the FCN1 gene, an association was found in the dominant and recessive genetic models of the variants rs2989727 (genotype TT = OR: 0.577, 95% CI: 0.430-0.769) and rs1071583 (genotype GG = OR: 1.537, 95% CI: 1.153-2.049, p = 0.0032) with the development of rheumatoid arthritis as a protective or susceptibility factor. FCN2 and FCN3 genes did not show association with disease development. The FCN1 gene variants rs2989727 and rs1071583 are associated with the risk of developing rheumatoid arthritis in populations from Brazil and Belgium, but not in FCN2 and FCN3 gene variants.

Abstract Image

FCN1、FCN2和FCN3基因多态性对类风湿关节炎易感性的影响:系统综述
在不同人群中进行的类风湿关节炎遗传关联研究产生了不同的结果。本系统综述综合研究结果,以确定ficolin编码基因FCN1、FCN2和FCN3多态性对类风湿关节炎易感性的影响。使用关键词“基因(FCN1/FCN2/FCN3)”、“多态性/遗传变异”和“类风湿关节炎”在不同的数据库中进行系统的文献综述,直到2022年1月。作者通过标题/摘要评估文章,然后通过全文评估数据提取。偏倚风险采用纽卡斯尔-渥太华量表进行评估。定性和定量地进行数据综合。共有1519篇文章符合纳入本综述的条件,其中3篇被确定为与670例患者和1019例对照的定量合成相关。对于FCN1基因,在显性和隐性遗传模型中发现变异rs2989727(基因型TT = OR: 0.577, 95% CI: 0.430-0.769)和rs1071583(基因型GG = OR: 1.537, 95% CI: 1.153-2.049, p = 0.0032)作为类风湿关节炎的保护或易感因素与类风湿关节炎的发生存在关联。FCN2和FCN3基因未显示与疾病发展相关。FCN1基因变异rs2989727和rs1071583与巴西和比利时人群发生类风湿性关节炎的风险相关,但与FCN2和FCN3基因变异无关。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
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