Fibroadenoma of the breast; incidence of malignancy and indicators for surgical intervention: An analysis of 1392 patients.

Breast disease Pub Date : 2022-01-01 DOI:10.3233/BD-210074

Waleed Elnahas, Islam H Metwally, Khaled Bonna, Marco Youssef, Samar AbdAllah, Mohamed Bonna, Mohamed Ali Faried, Mohamed Atef Tira, Omar Hamdy

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引用次数: 2

Abstract

Background: Fibroadenomas are common among young females. The size of the lesion used to be an indication for further assessment or excision. With arising of the watch and see proponents, criteria for selecting patients are important to establish.

Methods: This is a retrospective study of a prospectively maintained database where all patients having the clinical/radiological provisional diagnosis of fibroadenoma and attending our center - from January 2008 to March 2020 - were enrolled. The primary outcome was the incidence of malignancy and the secondary outcomes were the correlation of malignancy-risk with epidemiologic and radiologic criteria.

Results: The study enrolled 1392 patients. The mean age of the patients was 35.7 + ∕- 13.1 years. The median of the longest diameter of the detected breast lesions was 25 mm. The incidence of malignancy was 188 (13.5%). The size of the lesion measured by largest diameter was insignificant (p = 0.99), while the patients' age, marital status, and imaging criteria as measured by BIRADS score were significant (<0.001).

Conclusion: Approaching patients with the age above 35 or with BIRADS 4 provisionally diagnosed with fibroadenomas should be cautious with biopsy and short-term follow-ups The size of the tumor alone should not be used as an indication for surgical intervention.

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乳腺纤维腺瘤;恶性肿瘤发生率及手术干预指标:1392例患者分析

背景:纤维腺瘤常见于年轻女性。病变的大小曾经是进一步评估或切除的指示。随着“观察和观察”支持者的兴起，建立选择患者的标准变得非常重要。方法:这是一项前瞻性数据库的回顾性研究，其中纳入了2008年1月至2020年3月期间所有临床/放射学临时诊断为纤维腺瘤并在我们中心就诊的患者。主要结局是恶性肿瘤的发生率，次要结局是恶性肿瘤风险与流行病学和放射学标准的相关性。结果:该研究纳入了1392例患者。患者平均年龄为35.7±13.1岁。乳腺病灶最长直径中位数为25mm。恶性肿瘤188例(13.5%)。最大直径测量的病变大小差异无统计学意义(p = 0.99)，而BIRADS评分测量的患者年龄、婚姻状况、影像学标准差异有统计学意义(结论:接近35岁以上或BIRADS 4暂时诊断为纤维腺瘤的患者应谨慎活检和短期随访，肿瘤大小不应单独作为手术干预的指征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.