Protective Effect of Chrysin against Chlorpyrifos-Induced Metabolic Impairment and Pancreatitis in Male Rats.

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kobra Naseri, Mahdieh Safarzadeh, Mahdieh Rajabi Moghaddam, Hamed Aramjoo, Babak Roshanravan, Saeed Samarghandian, Tahereh Farkhondeh
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Abstract

Background: This study was performed to evaluate the protective effects of chrysin (CH) on metabolic impairment and pancreatic injury caused by sub-chronic chlorpyrifos (CPF) intoxication in male rats.

Methods: Forty male Wistar rats were randomly allocated into five groups (n=8). Intraperitoneal injections of chrysin (12.5, 25 and 50 mg/kg for 45 days) and CPF (10 mg/kg for 45 days) gavage were performed. Present findings indicated that the serum levels of glucose, total cholesterol, and lowdensity lipoprotein-cholesterol, as well as body weight, were increased in the CPF-exposed group.

Results: It was also found that CPF decreased superoxide dismutase activity as well as increased malondialdehyde and nitric oxide levels in the pancreatic tissue of exposed animals. Histopathological examination also confirmed the toxic effects of CPF on pancreatic tissue as mostly evidenced by infiltration of inflammatory cells and necrosis. CH (50 mg/kg) decreased blood glucose concentration (p < 0.05), TG (p < 0.05), and LDL-C in CPF-exposed animals. CH decreased the pancreas levels of MDA in all treated CPF-exposed groups versus the non-treated CPF-exposed group (p < 0.05, p < 0.001, p < 0.001, respectively). A significant difference was not seen in the NO and MDA levels and SOD activity between CH-treated (50 mg/kg) animals exposed to CPF and controls. A significant difference was not seen in the NO and MDA levels and SOD activity between CHtreated (50 mg/kg) animals exposed to CPF and controls.

Conclusion: A significant difference was not seen in the NO and MDA levels and SOD activity between CH-treated (50 mg/kg) animals exposed to CPF and controls. In conclusion, CH could prevent initiate and progress of CPF-induced metabolic impairment by modulating oxidative stress in pancreatic tissue as a target organ of organophosphorus pesticides.

菊花素对毒死蜱诱导的雄性大鼠代谢障碍和胰腺炎的保护作用。
背景:本研究旨在探讨金菊素(CH)对亚慢性毒死蜱(CPF)中毒引起的雄性大鼠代谢障碍和胰腺损伤的保护作用。方法:雄性Wistar大鼠40只,随机分为5组(n=8)。腹腔注射金菊素(12.5、25、50 mg/kg,连续45 d), CPF (10 mg/kg,连续45 d)灌胃。目前的研究结果表明,cpf暴露组的血清葡萄糖、总胆固醇和低密度脂蛋白-胆固醇水平以及体重都有所增加。结果:CPF还降低了暴露动物胰腺组织的超氧化物歧化酶活性,增加了丙二醛和一氧化氮水平。组织病理学检查也证实了CPF对胰腺组织的毒性作用,主要表现为炎症细胞浸润和坏死。CH (50 mg/kg)降低cpf暴露动物的血糖浓度(p < 0.05)、TG (p < 0.05)和LDL-C。在所有cpf暴露组中,与未cpf暴露组相比,CH降低了胰腺MDA水平(p < 0.05, p < 0.001, p < 0.001)。暴露于CPF的ch处理(50 mg/kg)动物与对照组之间,NO和MDA水平及SOD活性无显著差异。在暴露于CPF (50 mg/kg)的chf处理动物和对照组之间,NO和MDA水平以及SOD活性没有显著差异。结论:经ch处理(50 mg/kg)的CPF动物与对照组的NO、MDA水平及SOD活性无显著差异。综上所述,CH作为有机磷农药的靶器官,通过调节胰腺组织的氧化应激,可以预防cpf诱导的代谢损伤的发生和发展。
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来源期刊
Current molecular pharmacology
Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
4.90
自引率
3.70%
发文量
112
期刊介绍: Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.
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