Imputation of SNPs associated with presbycusis through linkage disequilibrium analysis in the ILDR1 gene.

IF 2.9 4区生物学 Q1 EDUCATION & EDUCATIONAL RESEARCH

Journal of Genetics Pub Date : 2023-01-01

Sergio V Flores, Alejandro Levi-Monsalve, Juan Pablo Alvarez-Lobo

引用次数: 0

Abstract

The single-nucleotide polymorphisms (SNP) ILDR1 rs2332035 has shown a high statistical association with presbycusis (hearing loss with age or age-related hearing impairment (ARHI)), according to genetic association studies in European populations. However, linked markers have not been surveyed. Here linkage disequilibrium (LD) of markers in ILDR1, in relation to rs2332035, is explored in the 2504 individuals from the 1000Genomes database. Of the 920 SNPs retrieved, 10 showed strong LD (r²= 0.8) in Europeans and Latin Americans, which are proposed here as candidate markers for both control-case association and cause-effect studies in both populations.

本刊更多论文

通过ILDR1基因连锁不平衡分析推测与老年性痴呆相关的snp。

根据欧洲人群的遗传关联研究，单核苷酸多态性(SNP) ILDR1 rs2332035与老年性耳聋(年龄或年龄相关性听力障碍(ARHI)的听力损失)具有高度的统计学相关性。然而，相关的标记尚未被调查。本文对来自1000Genomes数据库的2504个个体的ILDR1中与rs2332035相关的标记的连锁不平衡(LD)进行了研究。在检索到的920个snp中，10个在欧洲和拉丁美洲显示出很强的LD (r2= 0.8)，本文建议将其作为两种人群对照病例关联和因果研究的候选标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Genetics 生物-遗传学

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The journal retains its traditional interest in evolutionary research that is of relevance to geneticists, even if this is not explicitly genetical in nature. The journal covers all areas of genetics and evolution,including molecular genetics and molecular evolution.It publishes papers and review articles on current topics, commentaries and essayson ideas and trends in genetics and evolutionary biology, historical developments, debates and book reviews. From 2010 onwards, the journal has published a special category of papers termed ‘Online Resources’. These are brief reports on the development and the routine use of molecular markers for assessing genetic variability within and among species. Also published are reports outlining pedagogical approaches in genetics teaching.