Case report: Gastric adenosquamous carcinoma with EBV-positive component of squamous cell carcinoma mixed with gastric carcinoma with lymphoid stroma: A novel case report and literature review.

IF 2.3 4区医学 Q3 ONCOLOGY

Pathology & Oncology Research Pub Date : 2023-01-01 DOI:10.3389/pore.2023.1610902

Chang Lu, Jizhen Feng, Zhigang Yao, Lei Shi, Jiamei Li

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引用次数: 1

Abstract

Background: Gastric adenosquamous carcinoma with EBV-positive component of squamous cell carcinoma mixed with gastric carcinoma with lymphoid stroma are extremely unusual variants of gastric carcinoma. We herein reported such a case and summarized five related cases that have been reported previously. Case presentation: A 59-year-old man was admitted to our hospital with upper abdominal discomfort and acid reflux. Gastric endoscopic examination revealed an irregular ulcer in the gastric angle. Biopsy of the lesion revealed adenocarcinoma. The patient underwent laparoscopic distal gastrectomy with lymph node dissection subsequently. Histologically, the tumor showed coexistence of GASC and GCLS. SCC and GCLS were positive for EBER in situ hybridization, while adenocarcinoma component was negative. Accordingly, the present case was diagnosed as GASC with EBV-positive component of SCC mixed with GCLS. Conclusion: GASC with EBV-positive component of SCC mixed with GCLS is extremely rare. Although the pathogenesis of GASC and the role of EBV in the development of an ASC component have not been fully elucidated, this case will help clinicians and pathologists better understand this special subtype of gastric tumor.

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病例报告:胃腺鳞癌伴ebv阳性成分鳞状细胞癌合并胃癌伴淋巴样间质:一例新病例报告并文献复习。

背景:胃腺鳞状癌伴ebv阳性成分的鳞状细胞癌合并胃癌伴淋巴样间质是极为罕见的胃癌变型。本文报道该病例，并总结以往报道的5例相关病例。病例介绍:一名59岁男性因上腹部不适及胃酸反流入院。胃镜检查发现胃角处有不规则溃疡。病变活检显示为腺癌。患者随后行腹腔镜胃远端切除术并淋巴结清扫。组织学上，肿瘤表现为GASC和GCLS共存。SCC和GCLS细胞EBER原位杂交阳性，腺癌成分阴性。因此，本病例被诊断为GASC，并伴有ebv阳性SCC成分与GCLS混合。结论:GASC合并SCC ebv阳性组分与GCLS合并极为罕见。虽然GASC的发病机制和EBV在ASC成分发展中的作用尚未完全阐明，但本病例将有助于临床医生和病理学家更好地了解这种特殊的胃肿瘤亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology & Oncology Research 医学-病理学

CiteScore

6.30

自引率

0.00%

发文量

134

审稿时长

4-8 weeks

期刊介绍： Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.