Antidepressants use in Italy: an ecological study of national and regional trends and associated factors.

IF 2.1 3区医学 Q3 PHARMACOLOGY & PHARMACY

International Clinical Psychopharmacology Pub Date : 2024-03-01 Epub Date: 2023-11-15 DOI:10.1097/YIC.0000000000000522

Simone Amendola, Michael Pascal Hengartner

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引用次数: 0

Abstract

The present study aimed to (1) provide an update on trends in AD consumption both at the national and regional unit of analysis for the period 2000-2020 in Italy and (2) analyze sociodemographic and healthcare system-related factors associated with AD prescribing at the regional-population level between 2000 and 2019. Data were extracted from reports of the Italian Medicines Agency and databases of the Italian National Institute of Statistics. Linear regression and mixed models were applied to analyze trends in AD use (DDD/1000/day) and ecological factors associated with AD prescribing. Between 2000 and 2010 AD prescription rates constantly increased. Thereafter they stabilized until 2017 when a positive trend began again. There was a positive ecological association between AD prescribing and rates of hospital discharge due to affective disorders, antibiotics prescribing, public non-drug healthcare spending per capita, and Northern regions compared to Southern regions. AD consumption increased massively during the 2000s, flattened during the 2010s but thereafter increased again until 2020. The ecological correlation between healthcare provision/spending and AD consumption suggests that health-economic factors may play an important role.

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抗抑郁药在意大利的使用:国家和地区趋势及相关因素的生态学研究。

本研究旨在(1)提供2000-2020年期间意大利国家和地区分析单位AD消费趋势的最新信息，(2)分析2000年至2019年期间与区域人口水平AD处方相关的社会人口统计学和医疗系统相关因素。数据摘自意大利药品管理局的报告和意大利国家统计局的数据库。采用线性回归和混合模型分析AD使用趋势(DDD/1000/d)和与AD处方相关的生态因子。2000年至2010年间，AD处方率不断上升。此后，它们稳定下来，直到2017年再次开始出现积极趋势。AD处方与情感性障碍出院率、抗生素处方、人均公共非药物医疗支出以及北部地区与南部地区之间存在正相关的生态关系。广告消费在2000年代大幅增长，在2010年代趋于平缓，但此后再次增长，直到2020年。医疗保健提供/支出与AD消费之间的生态相关性表明，健康经济因素可能发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Clinical Psychopharmacology 医学-精神病学

CiteScore

4.40

自引率

23.10%

发文量

审稿时长

>12 weeks

期刊介绍： International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.