COVID-19 severity is associated with the risk of gastrointestinal bleeding.

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMJ Open Gastroenterology Pub Date : 2023-11-01 DOI:10.1136/bmjgast-2023-001199

Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto

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引用次数: 0

Abstract

Objective: The association between the severity of COVID-19 and gastrointestinal (GI) bleeding is unknown. This study aimed to determine whether the severity of COVID-19 is a risk factor for GI bleeding.

Design: A multicentre, retrospective cohort study was conducted on hospitalised patients with COVID-19 between January 2020 and December 2021. The severity of COVID-19 was classified according to the National Institute of Health severity classification. The primary outcome was the occurrence of GI bleeding during hospitalisation. The main analysis compared the relationship between the severity of COVID-19 and the occurrence of GI bleeding. Multivariable logistic regression analysis was performed to evaluate the association between the severity of COVID-19 and the occurrence of GI bleeding.

Results: 12 044 patients were included. 4165 (34.6%) and 1257 (10.4%) patients had severe and critical COVID-19, respectively, and 55 (0.5%) experienced GI bleeding. Multivariable analysis showed that patients with severe COVID-19 had a significantly higher risk of GI bleeding than patients with non-severe COVID-19 (OR: 3.013, 95% CI: 1.222 to 7.427). Patients with critical COVID-19 also had a significantly higher risk of GI bleeding (OR: 15.632, 95% CI: 6.581 to 37.130). Patients with severe COVID-19 had a significantly increased risk of lower GI bleeding (OR: 10.349, 95% CI: 1.253 to 85.463), but the risk of upper GI bleeding was unchanged (OR: 1.875, 95% CI: 0.658 to 5.342).

Conclusion: The severity of COVID-19 is associated with GI bleeding, and especially lower GI bleeding was associated with the severity of COVID-19. Patients with severe or critical COVID-19 should be treated with caution as they are at higher risk for GI bleeding.

查看原文本刊更多论文

COVID-19严重程度与胃肠道出血风险相关。

目的:COVID-19严重程度与胃肠道出血之间的关系尚不清楚。本研究旨在确定COVID-19的严重程度是否是胃肠道出血的危险因素。设计:在2020年1月至2021年12月期间，对COVID-19住院患者进行了一项多中心回顾性队列研究。根据美国国立卫生研究院的严重程度分类，对COVID-19的严重程度进行了分类。主要结局是住院期间消化道出血的发生。主要分析比较COVID-19严重程度与胃肠道出血发生的关系。采用多变量logistic回归分析评估COVID-19严重程度与胃肠道出血发生的相关性。结果:共纳入患者12044例。重症和危重型分别为4165例(34.6%)和1257例(10.4%)，消化道出血55例(0.5%)。多变量分析显示，重症COVID-19患者发生胃肠道出血的风险明显高于非重症COVID-19患者(OR: 3.013, 95% CI: 1.222 ~ 7.427)。重症COVID-19患者发生胃肠道出血的风险也明显更高(OR: 15.632, 95% CI: 6.581至37.130)。重症COVID-19患者下消化道出血的风险显著增加(OR: 10.349, 95% CI: 1.253 ~ 85.463)，但上消化道出血的风险不变(OR: 1.875, 95% CI: 0.658 ~ 5.342)。结论:COVID-19严重程度与胃肠道出血相关，特别是下消化道出血与COVID-19严重程度相关。重症或危重型COVID-19患者应谨慎治疗，因为他们发生胃肠道出血的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

5.90

自引率

3.20%

发文量

审稿时长

2 weeks

期刊介绍： BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.