Repetitive transcranial magnetic stimulation (rTMS) is associated with increased abstinence in substance use disorders and comorbid depression.

IF 1.5 4区医学 Q3 PSYCHIATRY

Annals of Clinical Psychiatry Pub Date : 2023-02-01 DOI:10.12788/acp.0094

Wael Foad, Karim Abdel Aziz, Maged Agour, Abdelazim Ali, Faris Alhammadi, Rami Alhawi, Samer Altamimi, Zahid Hussain, Amr Abdel Aty, Tarik Qassem

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引用次数: 0

Abstract

Background: Substance use disorders (SUDs) are associated with high rates of comorbid depression. Finding effective treatments for many of the substances of abuse is still an area of developing research. Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for depression, but its effects in SUDs are less conclusive. Therefore, we aimed to investigate the effect of rTMS in patients with SUDs and comorbid major depressive disorder (MDD).

Methods: We conducted a retrospective observational study of 55 patients with SUDs and comorbid MDD who were eligible for rTMS. Craving was measured using the Brief Substance Craving Scale (BSCS). Severity of MDD was measured using the Clinical Global Impression-Severity (CGI-S) scale.

Results: We found a statistically significant difference between baseline and posttreatment scores in patients receiving rTMS on both CGI-S scores and BSCS scores. The number of rTMS sessions significantly predicted increased days of abstinence in the community, even after controlling for confounders.

Conclusions: Patients with SUDs and MDD who received rTMS significantly improved in the areas of severity of depression and craving. The number of rTMS sessions significantly predicted increased abstinence.

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重复经颅磁刺激(rTMS)与物质使用障碍和共病抑郁症的戒断增加有关。

背景:物质使用障碍(sud)与高发生率的共病性抑郁症相关。为许多被滥用的物质寻找有效的治疗方法仍然是一个发展中的研究领域。重复经颅磁刺激(rTMS)是一种治疗抑郁症的既定方法，但其对sud的影响尚不明确。因此，我们旨在探讨rTMS对sud合并重度抑郁障碍(MDD)患者的影响。方法:我们对55例符合rTMS治疗条件的sud合并MDD患者进行了回顾性观察研究。渴望使用简短物质渴望量表(BSCS)进行测量。重度抑郁症的严重程度采用临床总体印象-严重程度(CGI-S)量表进行测量。结果:我们发现接受rTMS患者的基线评分和治疗后评分在CGI-S评分和BSCS评分上有统计学意义。即使在控制了混杂因素之后，rTMS的次数也显著地预测了社区中禁欲天数的增加。结论:接受rTMS治疗的sud和MDD患者在抑郁和渴望的严重程度方面有显著改善。rTMS的次数显著预测了禁欲的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Psychiatry PSYCHIATRY-

CiteScore

1.80

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： The ANNALS publishes up-to-date information regarding the diagnosis and /or treatment of persons with mental disorders. Preferred manuscripts are those that report the results of controlled clinical trials, timely and thorough evidence-based reviews, letters to the editor, and case reports that present new appraisals of pertinent clinical topics.