Which Areas Are Still Left in Biologics Responsive Korean Patients with Moderate to Severe Plaque Psoriasis.

IF 1.5 4区医学 Q3 DERMATOLOGY

Annals of Dermatology Pub Date : 2023-02-01 DOI:10.5021/ad.21.274

Sang-Hyeon Won, Bong Seok Shin, Kyung-Nam Bae, Jin-Hwa Son, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim

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引用次数: 0

Abstract

Background: Psoriasis localized to certain body areas, such as the scalp, nails, palms, soles, intertriginous regions, and genital regions, is reportedly difficult to treat.

Objective: To investigate the biologics-resistant areas in South Korean patients with psoriasis treated with biologics.

Methods: The study included 50 patients with chronic moderate to severe plaque psoriasis from the Pusan National University Hospital and Chosun University Hospital between October 2019 and September 2020. The patients had at least one psoriatic lesion, were treated with biologics for more than six months, and exhibited a partial or good response (reaching a Psoriasis Area and Severity Index [PASI] score of 1~5 after biologics treatment).

Results: A total of 50 patients with psoriasis (32 male, mean±standard deviation 47.8±11 years), with a median PASI score of 1.8, were included. The most common biologics-resistant areas were the anterior lower leg (56.0%), followed by the knee (48.0%) and posterior lower leg (42.0%). The proportion of biologics-resistant areas were obtained for body regions traditionally considered as difficult-to-treat entities, including the fingernails (10.0%), toenails (14.0%), scalp (38.0%), palm (12.0%), sole (14.0%), and genital areas (10.0%).

Conclusion: This study determined the biologics-resistant areas in South Korean patients, successfully treated with biologics, in a real-world clinical setting.

Abstract Image

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韩国中重度斑块型银屑病患者的生物制剂应答还有哪些领域有待改进?

背景:据报道，牛皮癣局限于某些身体部位，如头皮、指甲、手掌、脚底、三角区和生殖器区域，很难治疗。目的:了解韩国银屑病患者生物制剂耐药区。方法:该研究包括2019年10月至2020年9月期间在釜山国立大学医院和朝鲜大学医院就诊的50例慢性中重度斑块型银屑病患者。患者至少有一个银屑病病变，使用生物制剂治疗6个月以上，并表现出部分或良好的反应(生物制剂治疗后银屑病面积和严重程度指数[PASI]评分为1~5)。结果:共纳入50例银屑病患者(男性32例，平均±标准差47.8±11岁)，PASI评分中位数为1.8。最常见的耐药部位是小腿前部(56.0%)，其次是膝关节(48.0%)和小腿后部(42.0%)。传统上被认为难以治疗的身体部位，包括指甲(10.0%)、脚趾甲(14.0%)、头皮(38.0%)、手掌(12.0%)、鞋底(14.0%)和生殖部位(10.0%)，获得了生物制剂耐药区域的比例。结论:本研究确定了韩国患者的生物制剂耐药区域，这些患者在现实世界的临床环境中成功接受了生物制剂治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Dermatology 医学-皮肤病学

CiteScore

1.60

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Annals of Dermatology (Ann Dermatol) is the official peer-reviewed publication of the Korean Dermatological Association and the Korean Society for Investigative Dermatology. Since 1989, Ann Dermatol has contributed as a platform for communicating the latest research outcome and recent trend of dermatology in Korea and all over the world. Ann Dermatol seeks for ameliorated understanding of skin and skin-related disease for clinicians and researchers. Ann Dermatol deals with diverse skin-related topics from laboratory investigations to clinical outcomes and invites review articles, original articles, case reports, brief reports and items of correspondence. Ann Dermatol is interested in contributions from all countries in which good and advanced research is carried out. Ann Dermatol willingly recruits well-organized and significant manuscripts with proper scope throughout the world.