Meta-Analysis of the Use of Eimeria Lesion Scores and Oocyst Counts in Floor-Pen Studies.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Ruediger Hauck, Jordan Eckert, Colt Hunter
{"title":"Meta-Analysis of the Use of <i>Eimeria</i> Lesion Scores and Oocyst Counts in Floor-Pen Studies.","authors":"Ruediger Hauck,&nbsp;Jordan Eckert,&nbsp;Colt Hunter","doi":"10.1637/aviandiseases-D-22-00039","DOIUrl":null,"url":null,"abstract":"<p><p>The success of treatments for, or prophylaxis of, coccidiosis with classical anticoccidial feed additives or alternative treatments can be measured with a variety of metrics. Three important metrics are body weight or body weight gain (BW or BWG), lesion scores (LS), and oocyst shedding (OS). A meta-analysis of floor-pen experiments was performed to determine if using LS and OS would lead to systematically different assessments compared to the use of BW at the end of the experiment, and to what degree changes in LS and OS are correlated with BW. We also investigated if there were days postinfection on which one could expect larger ratios between untreated control groups and treated groups for LS and OS as an aid to selecting sampling days. A total of 38 experiments from 37 articles in peer-reviewed journals were included. Data sets containing experiments that investigated LS or OS in addition to BW or BWG to assess anticoccidial feed additives or alternative treatment were tested for the effectiveness of the intervention either by univariate meta-analyses for each metric or by robust variance estimation multivariate meta-analysis combining BW with LS or BW with OS. The results did not show evidence that the inclusion of LS and OS in experimental designs to assess the effect of conventional and alternative feed additives with assumed anticoccidial activity systematically changed the conclusions drawn from an experiment, but there was no significant correlation between the LS and OS ratios of untreated and treated groups determined during the experiments with the ratios of the BW at the end of the experiment for each experiment. There was also no discernible relationship between LS or OS ratios and days postinfection.</p>","PeriodicalId":8667,"journal":{"name":"Avian Diseases","volume":"66 4","pages":"381-388"},"PeriodicalIF":1.3000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avian Diseases","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1637/aviandiseases-D-22-00039","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

The success of treatments for, or prophylaxis of, coccidiosis with classical anticoccidial feed additives or alternative treatments can be measured with a variety of metrics. Three important metrics are body weight or body weight gain (BW or BWG), lesion scores (LS), and oocyst shedding (OS). A meta-analysis of floor-pen experiments was performed to determine if using LS and OS would lead to systematically different assessments compared to the use of BW at the end of the experiment, and to what degree changes in LS and OS are correlated with BW. We also investigated if there were days postinfection on which one could expect larger ratios between untreated control groups and treated groups for LS and OS as an aid to selecting sampling days. A total of 38 experiments from 37 articles in peer-reviewed journals were included. Data sets containing experiments that investigated LS or OS in addition to BW or BWG to assess anticoccidial feed additives or alternative treatment were tested for the effectiveness of the intervention either by univariate meta-analyses for each metric or by robust variance estimation multivariate meta-analysis combining BW with LS or BW with OS. The results did not show evidence that the inclusion of LS and OS in experimental designs to assess the effect of conventional and alternative feed additives with assumed anticoccidial activity systematically changed the conclusions drawn from an experiment, but there was no significant correlation between the LS and OS ratios of untreated and treated groups determined during the experiments with the ratios of the BW at the end of the experiment for each experiment. There was also no discernible relationship between LS or OS ratios and days postinfection.

在地板笔研究中使用艾美球粒损伤评分和卵囊计数的荟萃分析。
用经典的抗球虫饲料添加剂或替代治疗方法治疗或预防球虫病的成功可以用各种指标来衡量。三个重要的指标是体重或体重增加(BW或BWG),病变评分(LS)和卵囊脱落(OS)。我们对地板笔实验进行了荟萃分析,以确定在实验结束时,与使用体重相比,使用LS和OS是否会导致系统不同的评估,以及LS和OS的变化在多大程度上与体重相关。我们还调查了感染后是否存在未经治疗的对照组和治疗组之间LS和OS的比例较大的天数,以帮助选择采样天数。共纳入37篇同行评议期刊文章中的38个实验。除了体重或体重外,还研究了LS或OS以评估抗球虫饲料添加剂或替代治疗的实验数据集,通过对每个指标进行单变量荟萃分析,或通过将体重与LS或体重与OS结合进行稳健方差估计的多变量荟萃分析,对干预的有效性进行了测试。结果没有证据表明,在试验设计中加入LS和OS来评估具有抗球虫活性的常规和替代饲料添加剂的效果会系统性地改变试验得出的结论,但在试验期间测定的未处理组和处理组的LS和OS比与试验结束时的体重比之间没有显著相关性。LS或OS比率与感染后天数之间也没有明显的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Avian Diseases
Avian Diseases 农林科学-兽医学
CiteScore
2.40
自引率
7.10%
发文量
80
审稿时长
3 months
期刊介绍: Avian Diseases is an international journal dedicated to publishing original basic or clinical research of the highest quality from various disciplines including microbiology, immunology, pathology and epidemiology. Papers on avian diseases relevant to etiology, pathogenesis, diagnosis, treatment, and control are accepted. Manuscripts dealing with avian species other than poultry will be considered only if the subject is relevant to poultry health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信