On the sign of the average effect of an allele

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-12-01 DOI:10.1016/j.tpb.2022.10.001

Sabin Lessard , Warren J. Ewens

引用次数: 0

Abstract

The concept of the average effect of an allele pervades much of evolutionary population genetics. In this context the average effect of an allele is often considered as the main component of the “fitness” of that allele. It is widely believed that, if this fitness component for an allele is positive, then the frequency of this allele will increase, at least for one generation in discrete-time models. In this note we show that this is not necessarily the case since the average effect of an allele on fitness may be different from its marginal additive fitness even in a one-locus setting in non-random-mating populations.

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在等位基因平均效应的符号上

等位基因平均效应的概念在进化种群遗传学中广泛存在。在这种情况下，等位基因的平均效应通常被认为是该等位基因“适合度”的主要组成部分。人们普遍认为，如果一个等位基因的适应度成分是正的，那么这个等位基因的频率就会增加，至少在离散时间模型中会增加一代。在本文中，我们表明情况并非如此，因为即使在非随机交配种群的单位点环境中，等位基因对适应度的平均影响也可能与其边际附加适应度不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.