Vitamin A: A Key Inhibitor of Adipocyte Differentiation.

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
PPAR Research Pub Date : 2023-01-01 DOI:10.1155/2023/7405954
Manal A Malibary
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引用次数: 2

Abstract

Inhibiting adipocyte differentiation, the conversion of preadipocytes to mature functional adipocytes, might represent a new approach to treating obesity and related metabolic disorders. Peroxisome proliferator-activated receptor γ and CCAAT-enhancer-binding protein α are two master coregulators controlling adipogenesis both in culture and in vivo. Many recent studies have confirmed the relationship between retinoic acid (RA) and the conversion of embryonic stem cells into adipocytes; however, these studies have shown that RA potently blocks the differentiation of preadipocytes into mature adipocytes. Nevertheless, the functional role of RA in early tissue development and stem cell differentiation, including in adipose tissue, remains unclear. This study highlights transcription factors that block adipocyte differentiation and maintain preadipocyte status, focusing on those controlled by RA. However, some of these novel adipogenesis inhibitors have not been validated in vivo, and their mechanisms of action require further clarification.

Abstract Image

维生素A:脂肪细胞分化的关键抑制剂。
抑制脂肪细胞分化,将前脂肪细胞转化为成熟的功能性脂肪细胞,可能是治疗肥胖和相关代谢紊乱的新途径。过氧化物酶体增殖激活受体γ和ccaat增强结合蛋白α是两种主要的共调节因子,在培养和体内控制脂肪形成。最近的许多研究证实了维甲酸(RA)与胚胎干细胞转化为脂肪细胞之间的关系;然而,这些研究表明RA有效地阻断了前脂肪细胞向成熟脂肪细胞的分化。然而,RA在包括脂肪组织在内的早期组织发育和干细胞分化中的功能作用仍不清楚。本研究重点研究了阻断脂肪细胞分化和维持前脂肪细胞状态的转录因子,重点研究了由RA控制的转录因子。然而,这些新的脂肪生成抑制剂中的一些尚未在体内得到验证,其作用机制需要进一步阐明。
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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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