Pediatric Cerebral Meningioma: A Single-Center Study with 10 Children Not Associated with Neurofibromatosis Type 2 and Literature Review.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Pediatric Neurosurgery Pub Date : 2022-01-01 DOI:10.1159/000526541

Isabella Opoku, Liu Yang, Peng Sun, Mading Zhou, Yutong Liu, Jian Ren, Jianxin Du, Ling Feng, Gao Zeng

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引用次数: 1

Abstract

Introduction: Pediatric meningiomas (PMs) are rare tumors; they differ from their adult counterparts by their atypicality of location, higher rates of malignant change, male preponderance, recurrence, and sometimes, their association with neurofibromatosis. This case series analyzes the clinical behavior, pathological presentation, location, and its association with neurofibromatosis type 2 (NF2).

Methods: This case series consists of pediatric patients between the ages of 4 and 16 years who were hospitalized in the neurosurgical department of our hospital from 2012 to 2021 with different neurological symptoms and a literature review using the PubMed/MEDLINE database.

Results: Sixty percent of the patients were males, while 40% were females. The most common neurological manifestations were signs of increased intracranial pressure. NF2 was absent in all patients. The predominant histopathology subtypes are atypical and WHO grade II, representing 30% and 40%, respectively.

Conclusion: This study supports the relationship between NF2 and pediatric cerebral meningioma but at a lower concomitant rate from 0 to 13%, taking into consideration our original data and the literature review, contrasting some reported cases, which suggest rates as high as 33%, 50%, and 100% in a very small number of patients. Gross total resection without postoperative radiation therapy for nonmalignant and non-NF2-associated PM proved to be a sufficient and a good treatment option.

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儿童脑膜瘤:10例与2型神经纤维瘤病无关的儿童的单中心研究和文献综述

儿童脑膜瘤是一种罕见的肿瘤;他们不同于他们的成人同行的非典型性的位置，更高的恶性变化率，男性优势，复发，有时，他们与神经纤维瘤病的关联。本病例系列分析临床行为、病理表现、部位及其与2型神经纤维瘤病(NF2)的关系。方法:本病例系列包括2012年至2021年在我院神经外科住院的4至16岁的不同神经症状的儿童患者，并使用PubMed/MEDLINE数据库进行文献综述。结果:男性占60%，女性占40%。最常见的神经学表现是颅内压升高。所有患者均无NF2。主要的组织病理学亚型是非典型和WHO II级，分别占30%和40%。结论:考虑到我们的原始数据和文献综述，本研究支持NF2与儿童脑膜瘤之间的关系，但伴随率从0到13%较低，与一些报道的病例相比，在极少数患者中，NF2的发生率高达33%，50%和100%。非恶性和非nf2相关的PM经证实是一种充分和良好的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Neurosurgery 医学-临床神经学

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Articles in ''Pediatric Neurosurgery'' strives to publish new information and observations in pediatric neurosurgery and the allied fields of neurology, neuroradiology and neuropathology as they relate to the etiology of neurologic diseases and the operative care of affected patients. In addition to experimental and clinical studies, the journal presents critical reviews which provide the reader with an update on selected topics as well as case histories and reports on advances in methodology and technique. This thought-provoking focus encourages dissemination of information from neurosurgeons and neuroscientists around the world that will be of interest to clinicians and researchers concerned with pediatric, congenital, and developmental diseases of the nervous system.