Diagnosis and Treatment of Subcutaneous Panniculitis-like T-cell Lymphoma: A Systematic Literature Review.

Q1 Medicine

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2023-01-17 DOI:10.1016/j.hemonc.2021.04.001

Dunya Yunus Alsomali, Nasir Bakshi, Mohamed Kharfan-Dabaja, Riad El Fakih, Mahmoud Aljurf

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引用次数: 10

Abstract

Objectives: The aim of this systematic review is to investigate different diagnostic methods and the available treatment options for subcutaneous panniculitis-like T-cell lymphoma (SPTCL).

Methods: We searched PubMed, Web of Science, SCOPUS, EBSCO, and CINAHL Plus for published case reports of SPTCL. From each record, we extracted data of the diagnostic methods, immunohistochemical profile, clinical characteristics, and the treatment approaches provided. Data were summarized and narratively synthesized to highlight the various diagnostic methods and treatment options of SPTCL.

Results: Our literature search yielded 1293 unique citations. Following screening, nine articles reporting a total of 15 cases were included in this systematic review. All patients presented with subcutaneous nodules. Three of the 15 cases were initially misdiagnosed. The atypical lymphoid cells were positive for CD2, CD3, granzyme B, and TIA-1 and negative for CD1a, EBER, and CD20 in all the reported cases. The atypical lymphoid cells were positive for CD45RO in four out of seven cases, positive for CD56 in three out of 12 cases tested, while positive for CD5 and CD8 in the majority of cases. Therapy ranged from topical agents to immunosuppressive agents all the way to multiagent chemotherapy.

Conclusion: SPTCL is a rare lymphoma. Diagnosis is highly dependent on the immunohistochemical stains added to histopathologic and radiologic findings. Therapy is dependent on the pace of the disease, with encouraging results obtained with single-agent cyclosporine.

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皮下泛膜炎样t细胞淋巴瘤的诊断和治疗:系统文献综述。

目的:本系统综述的目的是探讨皮下泛膜炎样t细胞淋巴瘤(SPTCL)的不同诊断方法和可用的治疗方案。方法:检索PubMed、Web of Science、SCOPUS、EBSCO、CINAHL Plus等已发表的SPTCL病例报告。从每个记录中，我们提取了诊断方法、免疫组织化学特征、临床特征和治疗方法的数据。对资料进行总结和叙述综合，以突出SPTCL的各种诊断方法和治疗方案。结果:我们的文献检索得到1293个独特的引用。经过筛选，9篇报道15例病例的文章被纳入本系统综述。所有患者均表现为皮下结节。15例中有3例最初被误诊。非典型淋巴样细胞CD2、CD3、颗粒酶B和TIA-1阳性，CD1a、EBER和CD20阴性。非典型淋巴样细胞在7例中有4例CD45RO阳性，在12例中有3例CD56阳性，而在大多数病例中CD5和CD8阳性。治疗范围从局部药物到免疫抑制剂一直到多药化疗。结论:SPTCL是一种罕见的淋巴瘤。诊断高度依赖于免疫组织化学染色加上组织病理学和放射学检查结果。治疗取决于疾病的发展速度，单药环孢素获得了令人鼓舞的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology/ Oncology and Stem Cell Therapy Medicine-Hematology

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Hematology Oncology and Stem Cell Therapy is an international, peer-reviewed, open access journal that provides a vehicle for publications of high-quality clinical as well as basic science research reports in hematology and oncology. The contents of the journal also emphasize the growing importance of hematopoietic stem cell therapy for treatment of various benign and malignant hematologic disorders and certain solid tumors.The journal prioritizes publication of original research articles but also would give consideration for brief reports, review articles, special communications, and unique case reports. It also offers a special section for clinically relevant images that provide an important educational value.