{"title":"An Introduction to Stereology with Applications to the Glomerulus.","authors":"Kevin V Lemley","doi":"10.1159/000519719","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. Without a proper understanding of its principles, though, errors may be made in the quantitative reporting of structural research results.</p><p><strong>Summary: </strong>This review article attempts to explain and justify the basic principles of stereology as applied to the glomerulus in a simple and accessible way. A few common errors in application are described. The strengths and weaknesses of \"biased\" (model-based) stereology are described as well as the basics of design-based (\"unbiased\") stereology.</p><p><strong>Key messages: </strong>Stereology is a useful body of theory and practices when quantitation of structural histological features of the glomerulus is desired.</p>","PeriodicalId":73177,"journal":{"name":"Glomerular diseases","volume":"1 4","pages":"294-301"},"PeriodicalIF":0.0000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/a5/gdz-0001-0294.PMC9677735.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Glomerular diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000519719","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. Without a proper understanding of its principles, though, errors may be made in the quantitative reporting of structural research results.
Summary: This review article attempts to explain and justify the basic principles of stereology as applied to the glomerulus in a simple and accessible way. A few common errors in application are described. The strengths and weaknesses of "biased" (model-based) stereology are described as well as the basics of design-based ("unbiased") stereology.
Key messages: Stereology is a useful body of theory and practices when quantitation of structural histological features of the glomerulus is desired.
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