Would New SARS-CoV-2 Variants Change the War against COVID-19?

Epidemiolgia (Basel, Switzerland) Pub Date : 2022-04-29 DOI:10.3390/epidemiologia3020018

Elrashdy M Redwan, Fatma Elrashdy, Alaa A A Aljabali, Wagner Baetas-da-Cruz, Debmalya Barh, Adam M Brufsky, Sk Sarif Hassan, Kenneth Lundstrom, Ángel Serrano-Aroca, Kazuo Takayama, Murtaza M Tambuwala, Bruce D Uhal, Vladimir N Uversky

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引用次数: 2

Abstract

The scientific, private, and industrial sectors use a wide variety of technological platforms available to achieve protection against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), including vaccines. However, the virus evolves continually into new highly virulent variants, which might overcome the protection provided by vaccines and may re-expose the population to infections. Mass vaccinations should be continued in combination with more or less mandatory non-pharmaceutical interventions. Therefore, the key questions to be answered are: (i) How to identify the primary and secondary infections of SARS-CoV-2? (ii) Why are neutralizing antibodies not long-lasting in both cases of natural infections and post-vaccinations? (iii) Which are the factors responsible for this decay in neutralizing antibodies? (iv) What strategy could be adapted to develop long-term herd immunity? (v) Is the Spike protein the only vaccine target or is a vaccine cocktail better?

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新的SARS-CoV-2变种会改变对抗COVID-19的战争吗?

科学、私营和工业部门利用各种现有的技术平台，包括疫苗，实现对SARS-CoV-2(严重急性呼吸综合征冠状病毒2)的保护。然而，病毒不断演变成新的高毒力变体，这可能会克服疫苗提供的保护，并可能使人群再次暴露于感染之中。应继续进行大规模疫苗接种，同时采取或多或少的强制性非药物干预措施。因此，需要回答的关键问题是:(一)如何识别SARS-CoV-2的原发性和继发性感染?(二)为什么中和抗体在自然感染和接种疫苗后都不能持久?(iii)哪些因素导致了中和抗体的衰减?(四)可采用何种战略来发展长期群体免疫?(v)刺突蛋白是唯一的疫苗靶点，还是混合疫苗更好?

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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