Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in Turkiye: Systematic review.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Elmas Pinar Kahraman Kilbas, Imdat Kilbas, Ihsan Hakki Ciftci
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Abstract

The World Health Organization has designated carbapenem-resistant Acinetobacter baumannii (CRAB) as a "critical" pathogen on the global priority list of antibiotic-resistant bacteria. This study aims to discuss the molecular epidemiology of CRAB isolates in Turkiye in the last 12 years and the prevalence of gene regions associated with resistance or pathogenesis using a systematic review method. Our study consists of a literature search, determination of eligibility and exclusion criteria, qualitative analysis of studies, data extraction, and statistical analysis. All studies were analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. The incidence rates of blaOXA-23, blaOXA-23-like, blaOXA-24/40, blaOXA-24/40-like, blaOXA-51, blaOXA-51-like, blaOXA-58, and blaOXA-58-like genes in CRAB strains were 76.4%, 68.6%, 1.2%, 3.4%, 97.0%, 98.6%, 8.4%, and 17.1%, respectively. It was determined that the prevalence of the blaOXA-23 and blaOXA-58 gene regions showed a statistically significant change over the years. Due to the high prevalence of A. baumannii strains carrying the blaOXA-23 variant, it is necessary to follow its geographical distribution and transposon and plasmid movements. Based on available data, molecular surveillance of CRAB strains should be standardized. In addition, sterilization and disinfection processes applied within the scope of an effective struggle against CRAB strains that can remain live on surfaces for a long time should be reviewed frequently.

Abstract Image

Abstract Image

土耳其耐碳青霉烯鲍曼不动杆菌分离株的分子流行病学:系统综述。
世界卫生组织已将耐碳青霉烯鲍曼不动杆菌(CRAB)指定为全球抗生素耐药细菌优先清单上的“关键”病原体。本研究旨在采用系统综述的方法,探讨近12年来土耳其地区分离的CRAB的分子流行病学及与耐药性或发病机制相关的基因区域的流行情况。我们的研究包括文献检索、合格性和排除标准的确定、研究的定性分析、数据提取和统计分析。所有的研究都按照系统评价和荟萃分析指南的首选报告项目进行分析。blaOXA-23、blaOXA-23-like、blaOXA-24/40、blaOXA-24/40-like、blaOXA-51、blaOXA-51-like、blaOXA-58和blaOXA-58-like基因在CRAB菌株中的发病率分别为76.4%、68.6%、1.2%、3.4%、97.0%、98.6%、8.4%和17.1%。我们确定blaOXA-23和blaOXA-58基因区域的患病率在这些年里有统计学上显著的变化。由于鲍曼不动杆菌携带blaOXA-23变异株的高流行率,有必要跟踪其地理分布和转座子和质粒的运动。在现有资料的基础上,应规范螃蟹菌株的分子监测。此外,应经常审查在有效对抗可在表面长时间存活的螃蟹菌株范围内应用的灭菌和消毒过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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