Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Jill L. Silverman, Audrey Thurm, Sarah B. Ethridge, Makayla M. Soller, Stela P. Petkova, Ted Abel, Melissa D. Bauman, Edward S. Brodkin, Hala Harony-Nicolas, Markus Wöhr, Alycia Halladay
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引用次数: 42

Abstract

Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence-based interventions for core symptoms. With no established biological markers, diagnoses are defined by behavioral criteria. Thus, preclinical in vivo animal models of NDDs must be optimally utilized. For this reason, experts in the field of behavioral neuroscience convened a workshop with the goals of reviewing current behavioral studies, reports, and assessments in rodent models. Goals included: (a) identifying the maximal utility and limitations of behavior in animal models with construct validity; (b) providing recommendations for phenotyping animal models; and (c) guidelines on how in vivo models should be used and reported reliably and rigorously while acknowledging their limitations. We concluded by recommending minimal criteria for reporting in manuscripts going forward. The workshop elucidated a consensus of potential solutions to several problems, including revisiting claims made about animal model links to ASD (and related conditions). Specific conclusions included: mice (or other rodent or preclinical models) are models of the neurodevelopmental insult, not specifically any disorder (e.g., ASD); a model that perfectly recapitulates a disorder such as ASD is untenable; and greater attention needs be given to validation of behavioral testing methods, data analysis, and critical interpretation.

Abstract Image

重新考虑用于研究自闭症谱系障碍的动物模型:现状和优化未来
神经发育障碍(ndd),包括自闭症谱系障碍(ASD)和智力残疾(ID),是普遍存在的、往往是终身的疾病,缺乏针对核心症状的循证干预措施。由于没有确定的生物学标记,诊断是由行为标准定义的。因此,必须充分利用ndd的临床前体内动物模型。出于这个原因,行为神经科学领域的专家们召开了一次研讨会,目的是回顾当前啮齿动物模型的行为研究、报告和评估。目标包括:(a)确定具有构念效度的动物模型中行为的最大效用和局限性;(b)为动物模型的分型提供建议;(c)在承认其局限性的同时,如何可靠、严格地使用和报告体内模型的指导方针。最后,我们推荐了未来手稿报告的最低标准。研讨会阐明了对几个问题的潜在解决方案的共识,包括重新审视关于动物模型与ASD(及相关疾病)联系的说法。具体结论包括:小鼠(或其他啮齿动物或临床前模型)是神经发育损伤的模型,而不是特定的任何疾病(例如ASD);一个完美概括自闭症等疾病的模型是站不住脚的;并且需要更多地关注行为测试方法的验证、数据分析和批判性解释。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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