Under warm ambient conditions, Drosophila melanogaster suppresses nighttime activity via the neuropeptide pigment dispersing factor

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Aishwariya Srikala Iyengar, Rutvij Kulkarni, Vasu Sheeba
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引用次数: 2

Abstract

Rhythmic locomotor behaviour of flies is controlled by an endogenous time-keeping mechanism, the circadian clock, and is influenced by environmental temperatures. Flies inherently prefer cool temperatures around 25°C, and under such conditions, time their locomotor activity to occur at dawn and dusk. Under relatively warmer conditions such as 30°C, flies shift their activity into the night, advancing their morning activity bout into the early morning, before lights-ON, and delaying their evening activity into early night. The molecular basis for such temperature-dependent behavioural modulation has been associated with core circadian clock genes, but the neuronal basis is not yet clear. Under relatively cool temperatures such as 25°C, the role of the circadian pacemaker ventrolateral neurons (LNvs), along with a major neuropeptide secreted by them, pigment dispersing factor (PDF), has been showed in regulating various aspects of locomotor activity rhythms. However, the role of the LNvs and PDF in warm temperature-mediated behavioural modulation has not been explored. We show here that flies lacking proper PDF signalling or the LNvs altogether, cannot suppress their locomotor activity resulting in loss of sleep during the middle of the night, and thus describe a novel role for PDF signalling and the LNvs in behavioural modulation under warm ambient conditions. In a rapidly warming world, such behavioural plasticity may enable organisms to respond to harsh temperatures in the environment.

Abstract Image

在温暖的环境条件下,黑腹果蝇通过神经肽色素分散因子抑制夜间活动
苍蝇的节律性运动行为是由一种内源性的计时机制——生物钟控制的,并受到环境温度的影响。苍蝇天生就喜欢25°C左右的凉爽温度,在这种条件下,它们的运动活动发生在黎明和黄昏。在相对温暖的条件下,如30°C,苍蝇将它们的活动转移到夜间,将它们的早晨活动提前到凌晨,在灯亮之前,并将它们的夜间活动推迟到夜间。这种温度依赖性行为调节的分子基础与核心生物钟基因有关,但神经元基础尚不清楚。在相对较低的温度下,如25°C,昼夜节律起搏器腹侧神经元(LNvs)及其分泌的主要神经肽色素分散因子(PDF)在调节运动活动节律的各个方面的作用已被证明。然而,LNvs和PDF在温暖温度介导的行为调节中的作用尚未被探索。我们在这里表明,缺乏适当的PDF信号或LNvs的果蝇不能抑制它们的运动活动,导致半夜睡眠不足,从而描述了PDF信号和LNvs在温暖环境条件下行为调节中的新作用。在快速变暖的世界中,这种行为可塑性可能使生物体能够对环境中的恶劣温度做出反应。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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