Biological functions of α2-adrenergic-like octopamine receptor in Drosophila melanogaster

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-04-12 DOI:10.1111/gbb.12807

Hiroyuki Nakagawa, Shiori Maehara, Kazuhiko Kume, Hiroto Ohta, Jun Tomita

{"title":"Biological functions of α2-adrenergic-like octopamine receptor in Drosophila melanogaster","authors":"Hiroyuki Nakagawa, Shiori Maehara, Kazuhiko Kume, Hiroto Ohta, Jun Tomita","doi":"10.1111/gbb.12807","DOIUrl":null,"url":null,"abstract":"Octopamine regulates various physiological phenomena including memory, sleep, grooming and aggression in insects. In Drosophila, four types of octopamine receptors have been identified: Oamb, Oct/TyrR, OctβR and Octα2R. Among these receptors, Octα2R was recently discovered and pharmacologically characterized. However, the effects of the receptor on biological functions are still unknown. Here, we showed that Octα2R regulated several behaviors related to octopamine signaling. Octα2R hypomorphic mutant flies showed a significant decrease in locomotor activity. We found that Octα2R expressed in the pars intercerebralis, which is a brain region projected by octopaminergic neurons, is involved in control of the locomotor activity. Besides, Octα2R hypomorphic mutants increased time and frequency of grooming and inhibited starvation-induced hyperactivity. These results indicated that Octα2R expressed in the central nervous system is responsible for the involvement in physiological functions.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/34/GBB-21-e12807.PMC9744561.pdf","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/gbb.12807","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 4

Abstract

Octopamine regulates various physiological phenomena including memory, sleep, grooming and aggression in insects. In Drosophila, four types of octopamine receptors have been identified: Oamb, Oct/TyrR, OctβR and Octα2R. Among these receptors, Octα2R was recently discovered and pharmacologically characterized. However, the effects of the receptor on biological functions are still unknown. Here, we showed that Octα2R regulated several behaviors related to octopamine signaling. Octα2R hypomorphic mutant flies showed a significant decrease in locomotor activity. We found that Octα2R expressed in the pars intercerebralis, which is a brain region projected by octopaminergic neurons, is involved in control of the locomotor activity. Besides, Octα2R hypomorphic mutants increased time and frequency of grooming and inhibited starvation-induced hyperactivity. These results indicated that Octα2R expressed in the central nervous system is responsible for the involvement in physiological functions.

Abstract Image

查看原文本刊更多论文

黑腹果蝇α2-肾上腺素能样章鱼胺受体的生物学功能

章鱼胺调节各种生理现象，包括昆虫的记忆、睡眠、梳理和攻击。在果蝇中，已经鉴定出四种类型的章鱼胺受体:Oamb、Oct/TyrR、Octβ r和Octα 2r。在这些受体中，Octα2R是最近才被发现并进行药理学鉴定的。然而，受体对生物功能的影响尚不清楚。在这里，我们发现Octα2R调节了与章鱼胺信号传导相关的几种行为。Octα2R半胚突变体果蝇的运动活性显著降低。我们发现Octα2R在脑间部(章鱼胺能神经元投射的脑区)的表达参与了章鱼运动活动的控制。此外，Octα2R亚形态突变体增加了梳理的时间和频率，抑制了饥饿引起的多动。这些结果表明Octα2R在中枢神经系统的表达参与了生理功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464