Recent progress of gene circuit designs in immune cell therapies.

IF 9 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Seunghee Lee, Ahmad S Khalil, Wilson W Wong
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引用次数: 0

Abstract

The success of chimeric antigen receptor (CAR) T cell therapy against hematological cancers has convincingly demonstrated the potential of using genetically engineered cells as therapeutic agents. Although much progress has been achieved in cell therapy, more beneficial capabilities have yet to be fully explored. One of the unique advantages afforded by cell therapies is the possibility to implement genetic control circuits, which enables diverse signal sensing and logical processing for optimal response in the complex tumor microenvironment. In this perspective, we will first outline design considerations for cell therapy control circuits that address clinical demands. We will compare and contrast key design features in some of the latest control circuits developments and conclude by discussing potential future directions.

基因回路设计在免疫细胞治疗中的最新进展。
嵌合抗原受体(CAR) T细胞治疗血液病的成功令人信服地证明了使用基因工程细胞作为治疗剂的潜力。虽然在细胞治疗方面已经取得了很大的进展,但更多有益的能力尚未得到充分的探索。细胞疗法提供的独特优势之一是实现遗传控制电路的可能性,这使得多种信号传感和逻辑处理在复杂的肿瘤微环境中获得最佳反应。从这个角度来看,我们将首先概述解决临床需求的细胞治疗控制电路的设计考虑。我们将比较和对比一些最新控制电路发展的关键设计特征,并通过讨论潜在的未来方向来结束。
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来源期刊
Cell Systems
Cell Systems Medicine-Pathology and Forensic Medicine
CiteScore
16.50
自引率
1.10%
发文量
84
审稿时长
42 days
期刊介绍: In 2015, Cell Systems was founded as a platform within Cell Press to showcase innovative research in systems biology. Our primary goal is to investigate complex biological phenomena that cannot be simply explained by basic mathematical principles. While the physical sciences have long successfully tackled such challenges, we have discovered that our most impactful publications often employ quantitative, inference-based methodologies borrowed from the fields of physics, engineering, mathematics, and computer science. We are committed to providing a home for elegant research that addresses fundamental questions in systems biology.
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