Comparative outcomes of hemodialysis patients facing pre-Omicron and Omicron COVID-19 epidemics.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2024-02-01 Epub Date: 2023-09-19 DOI:10.1111/1744-9987.14067

Hiroko Beppu, Tatsuya Fukuda, Naoya Otsubo, Taro Akihisa, Tomoko Kawanishi, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Chise Sugita, Yoshiaki Kikkawa, Tetsuya Yamada, Sachiko Wakai

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引用次数: 0

Abstract

Introduction: This study elucidates factors affecting the severity and mortality in pre-Omicron and Omicron strains of SARS-CoV-2 and vaccination impact.

Methods: This single-center retrospective observational study included 1598 hospitalized COVID-19 patients. Patients were grouped into "pre-Omicron" and "Omicron" periods. The endpoint was severe COVID-19 (oxygen saturation [SpO₂ ] < 94%). Logistic regression examined associations between clinical factors, including hemodialysis (HD), and the endpoint.

Results: The HD patient mortality rate dropped from 16% pre-Omicron to 4% during the Omicron epidemic. HD was significantly associated with the study endpoint in both epidemics. Unvaccinated patients had a greater risk of reaching the study endpoint among patients receiving HD.

Conclusion: These findings suggest that the Omicron variant, alongside vaccination and healthcare innovations, led to improved prognoses for HD patients with COVID-19. However, HD patients remain at a greater risk for severe COVID-19. Increased vaccination rates and optimized healthcare resources can improve this vulnerable population's prognoses.

查看原文本刊更多论文

面临前欧米克龙和欧米克龙 COVID-19 流行病的血液透析患者的疗效比较。

引言本研究阐明了影响 SARS-CoV-2 前 Omicron 和 Omicron 株严重程度和死亡率的因素以及疫苗接种的影响：这项单中心回顾性观察研究包括 1598 名住院的 COVID-19 患者。患者被分为 "前 Omicron "期和 "Omicron "期。研究终点为严重 COVID-19（血氧饱和度 [SpO2] 结果）：HD 患者的死亡率从 Omicron 流行前的 16% 降至 Omicron 流行期间的 4%。在两次疫情中，HD 都与研究终点有明显关联。在接受 HD 的患者中，未接种疫苗的患者达到研究终点的风险更大：这些研究结果表明，奥米克龙变体以及疫苗接种和医疗保健创新改善了 COVID-19 HD 患者的预后。然而，HD 患者发生严重 COVID-19 的风险仍然较大。提高疫苗接种率和优化医疗保健资源可改善这一弱势群体的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.