A scoping review and comparison of approaches for measuring genetic heterogeneity in psychiatric disorders.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2022-02-01 DOI:10.1097/YPG.0000000000000304

Harvey Wang, Martin Alda, Thomas Trappenberg, Abraham Nunes

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引用次数: 1

Abstract

An improved understanding of genetic etiological heterogeneity in a psychiatric condition may help us (a) isolate a neurophysiological 'final common pathway' by identifying its upstream genetic origins and (b) facilitate characterization of the condition's phenotypic variation. This review aims to identify existing genetic heterogeneity measurements in the psychiatric literature and provides a conceptual review of their mechanisms, limitations, and assumptions. The Scopus database was searched for studies that quantified genetic heterogeneity or correlation of psychiatric phenotypes with human genetic data. Ninety studies were included. Eighty-seven reports quantified genetic correlation, five applied genomic structural equation modelling, three evaluated departure from the Hardy-Weinberg equilibrium at one or more loci, and two applied a novel approach known as MiXeR. We found no study that rigorously measured genetic etiological heterogeneity across a large number of markers. Developing such approaches may help better characterize the biological diversity of psychopathology.

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精神疾病遗传异质性测量方法的范围回顾和比较。

提高对精神疾病遗传病因异质性的理解可以帮助我们(a)通过识别其上游遗传起源分离神经生理“最终共同途径”，(b)促进对疾病表型变异的表征。本综述旨在确定现有的精神病学文献中的遗传异质性测量方法，并对其机制、局限性和假设进行概念性回顾。在Scopus数据库中搜索量化遗传异质性或精神病学表型与人类遗传数据相关的研究。纳入了90项研究。87份报告量化了遗传相关性，5份应用了基因组结构方程模型，3份评估了一个或多个位点偏离Hardy-Weinberg平衡的情况，2份应用了一种称为MiXeR的新方法。我们没有发现任何研究严格地测量了大量标记物的遗传病因异质性。发展这样的方法可能有助于更好地描述精神病理学的生物多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.