Drug safety of frequently used drugs and substances for self-medication in COVID-19.

IF 3.4 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Therapeutic Advances in Drug Safety Pub Date : 2022-04-21 eCollection Date: 2022-01-01 DOI:10.1177/20420986221094141
Daniela Baracaldo-Santamaría, Santiago Pabón-Londoño, Luis Carlos Rojas-Rodriguez
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引用次数: 0

Abstract

During the COVID-19 pandemic, the behavior of self-medication has increased. The dissemination of misleading information regarding the efficacy of certain drugs or substances for the prevention and treatment of COVID-19 has been the major contributing factor for this phenomenon. Alongside with the increase in self-medication behavior, the inherent risks to this act such as drug-drug interactions, adverse events, drug toxicity, and masking of symptoms have also increased. Self-medication in the context of COVID-19 has led to drug misuse leading in some cases to the development of fatal adverse drug reactions. It is important that during this ongoing pandemic drugs with potential clinical efficacy against COVID-19 are adequately analyzed regarding their efficacy, safety, and monitoring. The aim of this review is to describe the available evidence regarding the efficacy, safety, and monitoring of the drugs and substances that have been shown to be frequently used for self-medication in patients with COVID-19 (hydroxychloroquine, non-steroidal anti-inflammatory drugs, ivermectin, azithromycin, vitamins, aspirin, and chlorine dioxide) to adequately characterize their risks, safe use, monitoring strategies, and to reinforce the concept that these substances should not be used for self-medication and require a medical prescription.

Plain language summary: Drug safety of frequently used drugs and substances for self-medication in COVID-19 Dissemination of information about potential COVID-19 treatments has led individuals to self-medicate and expose themselves to risks such as drug-drug interactions, side effects, antibiotic resistance, and misdiagnosis. There is a need to review the medical literature to evaluate the safety and efficacy of the drugs and substances commonly used by the population for the treatment and prevention of SARS CoV-2 infection. In this review, we included drugs that are frequently used for self-medication and commonly advertised such as ivermectin, hydroxychloroquine, chlorine dioxide, azithromycin, and non-steroidal anti-inflammatory drugs, among others. A brief introduction of the drug and its mechanism of action, followed by a summary of the efficacy in COVID-19 and safety, will be described for each drug in order to promote their responsible use.

Abstract Image

COVID-19 中常用药物和自我药疗物质的药物安全性。
在 COVID-19 大流行期间,自我药疗行为有所增加。关于某些药物或物质对预防和治疗 COVID-19 的疗效的误导性信息的传播是导致这一现象的主要因素。随着自我药疗行为的增加,这种行为的内在风险也在增加,如药物间相互作用、不良事件、药物毒性和掩盖症状等。在 COVID-19 的背景下,自我药疗导致了药物滥用,在某些情况下引发了致命的药物不良反应。重要的是,在这一持续的大流行期间,对具有潜在临床疗效的 COVID-19 药物进行充分的疗效、安全性和监测分析。本综述旨在描述已被证实经常用于 COVID-19 患者自我医疗的药物和物质(羟氯喹、非甾体抗炎药、伊维菌素、阿奇霉素、维生素、阿司匹林和二氧化氯)在疗效、安全性和监测方面的现有证据,以充分描述其风险特征、安全使用和监测策略,并强化这些物质不应用于自我医疗且需要医生处方的概念。通俗易懂的语言摘要:COVID-19 中用于自我药疗的常用药物和物质的药物安全性 COVID-19 潜在治疗信息的传播导致人们自我药疗,并面临药物间相互作用、副作用、抗生素耐药性和误诊等风险。有必要对医学文献进行回顾,以评估人们常用的治疗和预防 SARS CoV-2 感染的药物和物质的安全性和有效性。在这篇综述中,我们纳入了伊维菌素、羟氯喹、二氧化氯、阿奇霉素和非甾体抗炎药等经常用于自我治疗和常见广告宣传的药物。每种药物都将简要介绍药物及其作用机制,然后概述在 COVID-19 中的疗效和安全性,以促进负责任地使用这些药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Therapeutic Advances in Drug Safety
Therapeutic Advances in Drug Safety Medicine-Pharmacology (medical)
CiteScore
6.70
自引率
4.50%
发文量
31
审稿时长
9 weeks
期刊介绍: Therapeutic Advances in Drug Safety delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies pertaining to the safe use of drugs in patients. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in drug safety, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest on research across all areas of drug safety, including therapeutic drug monitoring, pharmacoepidemiology, adverse drug reactions, drug interactions, pharmacokinetics, pharmacovigilance, medication/prescribing errors, risk management, ethics and regulation.
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